Travel Information
Compare bus, train, and flight for Mannheim to Prague
Omio recommends booking the train as it is the most popular option from Mannheim to Prague among Omio's users. If you are prioritising price take the bus with prices starting from €25. For those with little time consider booking a flight which can get you there in 2h 2m. In case you are seeking to minimise your carbon footprint the train is your best bet as it emits only 0.1 - 0.4kg. The ticket price range depends on the travel mode: a bus costs an average of €25, and a flight costs an average of €125.
Distance: 431 km
Compare train with
Most popular Train | Bus | Flight |
|---|---|---|
€95 Average price | €42 Average price Cheapest | €180 Average price |
9h 42m Average total duration 9h 12m Onboard + 30m Additional time* | 6h 53m Average total duration 6h 23m Onboard + 30m Additional time* | 5h 2m Average total duration Fastest 2h 2m Onboard + 3h 0m Additional time* |
0.1 - 0.4kg CO2 emissions Lowest | 0.4 - 1.1kg CO2 emissions | 1.3 - 2.6kg CO2 emissions |
![]() Most popular train company | ![]() Most popular bus company | ![]() Most popular airline |
Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
Travel optionsfrom Mannheim to Prague
How to get from Mannheim to Prague by train, bus or flight.
Our recommendation
The best way to travel from Mannheim to Prague is by taking a train because it’s the best combination of price and speed.
ICE 575 · 88619 · 3573+
36112:00 PM8h21Mannheim Hbf8:21 PMPrague hlavní nádraží€441One-way3 transfers
Cheapest
ICE 575 · 88619 · 3573+
36112:00 PM8h21Mannheim Hbf8:21 PMPrague hlavní nádraží€441One-way3 transfers
Fastest
DE44117:30 PM1h00Frankfurt am Main Airport8:30 PMPrague Vaclav Havel Airport€1451One-way0 transfers
Other options
ICE 770 · ICE 625 · 3573+
36112:03 PM8h18Mannheim Hbf8:21 PMPrague hlavní nádraží€491One-way3 transfers
ICE 578 · ICE 629 · 3577+
3632:03 PM8h19Mannheim Hbf10:22 PMPrague hlavní nádraží€491One-way3 transfers
ICE 596 · IC 2047 · RJ 1793:29 PM8h02Mannheim Hbf11:31 PMPrague hlavní nádraží€501One-way2 transfers
FlixBus3:25 AM6h40Mannheim, ZOB (Heinrich-Von-Stephan-Straße)10:05 AMPraha, Na Knížecí€451One-way0 transfers
FlixBus3:25 AM7h10Mannheim, ZOB (Heinrich-Von-Stephan-Straße)10:35 AMPraha, ÚAN Florenc€451One-way0 transfers
FlixBus · FlixBus9:20 PM9h35Mannheim, ZOB (Heinrich-Von-Stephan-Straße)6:55 AMPraha, ÚAN Florenc€491One-way1 transfer
DE440910:00 AM1h00Frankfurt am Main Airport11:00 AMPrague Vaclav Havel Airport€1571One-way0 transfers
TGV 9551+
4258+
DE441112:19 PM8h11Mannheim Hbf8:30 PMPrague Vaclav Havel Airport€1681One-way2 transfers
ICE 106+
DE44113:33 PM4h57Mannheim Hbf8:30 PMPrague Vaclav Havel Airport€1691One-way1 transfer
Find all the dates and times for this journey by train, bus, flight, and ferry .
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FAQs: Travel from Mannheim to Prague
Travel to Prague easily. Whether you want fast, cheap or something entirely different, our travel experts have collected everything you need to know so you can find the best option from Mannheim to Prague.

This is compared to other travel options from Mannheim to Prague:
A bus is €53 less than a train for this route with tickets for a train from Mannheim to Prague costing on average €95.
A bus is €138 less than a flight for this route with tickets for a flight from Mannheim to Prague costing on average €180.
Other travel options to Prague take longer:
Bus takes on average 6h 23m.
Train takes on average 9h 12m.
- Around 60 flights per day.
- Around 11 trains per day.
- Around 7 buses per day.
However, we recommend checking specific travel dates for your route between Mannheim and Prague as scheduled services by bus, train, and flight can vary by season or day of the week.
- Flights mostly depart from Frankfurt am Main Airport and arrive in Prague Vaclav Havel Airport.
- Trains mostly depart from Mannheim Hbf and arrive in Prague hlavní nádraží.
- Buses mostly depart from Mannheim, ZOB (Heinrich-Von-Stephan-Straße) and arrive in Praha, ÚAN Florenc.
- Travel with Lufthansa, Lot Polish Airlines to go to Prague by flight.
- Travel with alex-Länderbahn und Vogtlandbahn-GmbH, Deutsche Bahn, České dráhy, ÖBB, Deutsche Bahn Intercity (DB IC) to go to Prague by train.
- Travel with FlixBus, BlaBlaCar to go to Prague by bus.
- 0 direct trains per day with ÖBB.
- 8 direct flights per day with Lufthansa.
- 6 direct buses per day with FlixBus, BlaBlaCar.
Travelling from Mannheim to Prague: related information
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