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Compare bus, train, and flight for Frankfurt am Main to Prague
Omio recommends booking the bus as it is the most popular option from Frankfurt am Main to Prague among Omio's users. If you are prioritising price, take the bus, with an average ticket price of €37 For those with little time, consider booking a flight, which has an average total journey time of 4h 55m. If you are seeking to minimise your carbon footprint, the train is your best option, with estimated CO2 emissions of 0.1 - 0.4kg. Average ticket prices depend on the travel mode: a bus costs an average of €37, while a flight costs an average of €334.
Distance: 409 km
Compare bus with
Most popular Bus | Train | Flight | Driving |
|---|---|---|---|
€37 Average price Cheapest | €81 Average price | €334 Average price | €93 Average price (fuel + tolls) |
8h 25m Average total duration 7h 55m Onboard + 30m Additional time* | 7h 34m Average total duration 7h 4m Onboard + 30m Additional time* | 4h 55m Average total duration Fastest 2h 55m Onboard + 2h 0m Additional time* | 5h 38m Average total duration (door-to-door) |
0.4 - 1.0kg CO2 emissions | 0.1 - 0.4kg CO2 emissions Lowest | 1.2 - 2.5kg CO2 emissions | - CO2 emissions |
![]() Most popular bus company | ![]() Most popular train company | ![]() Most popular airline | Your own car or car rental |
Direct Options | Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
Compare ways to travel from Frankfurt am Main to Prague
Compare the available ways to get from Frankfurt am Main to Prague, with the key details around price, speed, convenience, and direct service.
This is compared to other travel options from Frankfurt am Main to Prague:
A bus is €45 less than a train for this route with tickets for a train from Frankfurt am Main to Prague costing on average €81.
A bus is €298 less than a flight for this route with tickets for a flight from Frankfurt am Main to Prague costing on average €334.
Other travel options to Prague take longer:
Train takes on average 7h 34m.
Bus takes on average 8h 25m.
Travel optionsfrom Frankfurt am Main to Prague
How to get from Frankfurt am Main to Prague by train, bus or flight.
Our recommendation
The best way to travel from Frankfurt am Main to Prague is by taking a bus because it’s the best combination of price and speed.
(Amsterdam -> Prague)10:30 PM 6h18 Frankfurt, Stuttgarter Straße (Fermomnibusbahnhof) 4:48 AM Praha, ÚAN Florenc €30 1 One-way 0 transfers
Cheapest
(Amsterdam -> Prague)10:30 PM 6h18 Frankfurt, Stuttgarter Straße (Fermomnibusbahnhof) 4:48 AM Praha, ÚAN Florenc €30 1 One-way 0 transfers
Fastest
DE44829:55 AM 1h00 Frankfurt am Main Airport 10:55 AM Prague Vaclav Havel Airport €138 1 One-way 0 transfers
Other options
ICE 629 · Sp 5293 · IC 5672:57 PM 8h24 Frankfurt (Main) Hbf 11:21 PM Prague hlavní nádraží €33 1 One-way 2 transfers
ICE 625 · 3573 · Bus RE25 · EX 36112:57 PM 7h24 Frankfurt (Main) Hbf 8:21 PM Prague hlavní nádraží €33 1 One-way 3 transfers
ICE 629 · 3577 · Bus RE25 · EX 3632:57 PM 7h25 Frankfurt (Main) Hbf 10:22 PM Prague hlavní nádraží €33 1 One-way 3 transfers
FlixBus10:40 AM 8h30 Frankfurt am Main, Flughafen Frankfurt (Terminal 1 - Busparkplatz P36) 7:10 PM Praha, Na Knížecí €35 1 One-way 0 transfers
FlixBus10:40 AM 8h55 Frankfurt am Main, Flughafen Frankfurt (Terminal 1 - Busparkplatz P36) 7:35 PM Praha, ÚAN Florenc €35 1 One-way 0 transfers
FlixBus11:30 PM 7h25 Frankfurt am Main, Flughafen Frankfurt (Terminal 1 - Busparkplatz P36) 6:55 AM Praha, ÚAN Florenc €38 1 One-way 0 transfers
DE44808:10 PM 1h00 Frankfurt am Main Airport 9:10 PM Prague Vaclav Havel Airport €138 1 One-way 0 transfers
DE44842:30 PM 1h00 Frankfurt am Main Airport 3:30 PM Prague Vaclav Havel Airport €150 1 One-way 0 transfers
LO382 · LO52110:35 AM 6h40 Frankfurt am Main Airport 5:15 PM Prague Vaclav Havel Airport €238 1 One-way 1 transfer
Find all the dates and times for this journey by train, bus, flight, and ferry .
Compare prices and tickets Prices for trains, buses and flights
Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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FAQs: Travel from Frankfurt am Main to Prague
Travel to Prague easily. Whether you want fast, cheap or something entirely different, our travel experts have collected everything you need to know so you can find the best option from Frankfurt am Main to Prague.

This is compared to other travel options from Frankfurt am Main to Prague:
A bus is €45 less than a train for this route with tickets for a train from Frankfurt am Main to Prague costing on average €81.
A bus is €298 less than a flight for this route with tickets for a flight from Frankfurt am Main to Prague costing on average €334.
Other travel options to Prague take longer:
Train takes on average 7h 34m.
Bus takes on average 8h 25m.
- Around 51 flights per day.
- Around 27 buses per day.
- Around 21 trains per day.
However, we recommend checking specific travel dates for your route between Frankfurt am Main and Prague as scheduled services by bus, train, and flight can vary by season or day of the week.
- Flights mostly depart from Frankfurt am Main Airport and arrive in Prague Vaclav Havel Airport.
- Trains mostly depart from Frankfurt (Main) Hbf and arrive in Prague hlavní nádraží.
- Buses mostly depart from Frankfurt, Stuttgarter Straße (Fermomnibusbahnhof) and arrive in Praha, ÚAN Florenc.
- Travel with FlixBus, KLR, Infobus to go to Prague by bus.
- Travel with Deutsche Bahn, alex-Länderbahn und Vogtlandbahn-GmbH, České dráhy, Leo Express to go to Prague by train.
- Travel with Lufthansa, KLM, Lot Polish Airlines, KLM Cityhopper, Austrian Airlines, Condor Flugdienst, British Airways, Qatar Airways, Air Dolomiti, Air Baltic, Turkish Airlines, Swiss, Lufthansa Cityline, Brussels Airlines, Air France, CitizenPlane, TAP Portugal, Helvetic Airways, Edelweiss Air, Air Serbia, Cityjet to go to Prague by flight.
- 13 direct buses per day with FlixBus, KLR, Infobus.
- 1 direct trains per day with Leo Express.
- 8 direct flights per day with Lufthansa, Condor Flugdienst, Air Dolomiti, CitizenPlane.
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