Travel Information
Compare train, bus, and flight for Santander to Madrid
Omio recommends booking the train as it is the most popular option from Santander to Madrid among Omio's users. If you are prioritising price, take the train, with an average ticket price of €45 For those with little time, consider booking a flight, which has an average total journey time of 4h 42m. If you are seeking to minimise your carbon footprint, the train is your best option, with estimated CO2 emissions of 0.1 - 0.3kg. Average ticket prices depend on the travel mode: a train costs an average of €45, while a flight costs an average of €255.
Distance: 339 km
Compare train with
Most popular Train | Bus | Flight | Driving |
|---|---|---|---|
€45 Average price Cheapest | €46 Average price | €255 Average price | €66 Average price (fuel + tolls) |
4h 50m Average total duration 4h 20m Onboard + 30m Additional time* | 6h 26m Average total duration 5h 56m Onboard + 30m Additional time* | 4h 42m Average total duration Fastest 2h 42m Onboard + 2h 0m Additional time* | 4h 41m Average total duration (door-to-door) |
0.1 - 0.3kg CO2 emissions Lowest | 0.3 - 0.8kg CO2 emissions | 1.0 - 2.0kg CO2 emissions | - CO2 emissions |
![]() Most popular train company | ![]() Most popular bus company | ![]() Most popular airline | Your own car or car rental |
Direct Options | Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
This is compared to other travel options from Santander to Madrid:
A train is €1 less than a bus for this route with tickets for a bus from Santander to Madrid costing on average €46.
A train is €210 less than a flight for this route with tickets for a flight from Santander to Madrid costing on average €255.
Other travel options to Madrid take longer:
Train takes on average 4h 50m.
Bus takes on average 6h 26m.
Travel optionsfrom Santander to Madrid
How to get from Santander to Madrid by train, bus or flight.
Our recommendation
The best way to travel from Santander to Madrid is by taking a bus because it’s the best combination of price and speed.
Normal5:30 PM5h30Santander, Estación de Autobuses11:00 PMMadrid, Intercambiador de Avenida de América€391One-way0 transfers
Cheapest
Normal5:30 PM5h30Santander, Estación de Autobuses11:00 PMMadrid, Intercambiador de Avenida de América€391One-way0 transfers
Fastest
041927:00 PM4h20Santander station11:20 PMMadrid Chamartín€461One-way0 transfers
Other options
04072+
180107:05 AM6h20Santander station1:25 PMMadrid Príncipe Pío€501One-way1 transfer
18102+
180049:20 AM8h09Santander station5:29 PMMadrid Príncipe Pío€501One-way1 transfer
04072+
180047:05 AM10h24Santander station5:29 PMMadrid Príncipe Pío€501One-way1 transfer
Normal8:00 AM5h40Santander, Estación de Autobuses1:40 PMMadrid, Terminal de autobuses T4 (Aeropuerto de Madrid)€411One-way0 transfers
Normal8:00 AM5h50Santander, Estación de Autobuses1:50 PMMadrid, Intercambiador de Avenida de América€411One-way0 transfers
Normal10:30 AM6h15Santander, Estación de Autobuses4:45 PMMadrid, Intercambiador de Avenida de América€411One-way0 transfers
Find all the dates and times for this journey by train, bus, flight, and ferry .
Compare prices and tickets Prices for trains, buses and flights
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FAQs: Travel from Santander to Madrid
Travel to Madrid easily. Whether you want fast, cheap or something entirely different, our travel experts have collected everything you need to know so you can find the best option from Santander to Madrid.

This is compared to other travel options from Santander to Madrid:
A train is €23 less than a bus for this route with tickets for a bus from Santander to Madrid costing on average €48.
A train is €179 less than a flight for this route with tickets for a flight from Santander to Madrid costing on average €205.
Other travel options to Madrid take longer:
Train takes on average 5h 19m.
Bus takes on average 7h 36m.
- Around 15 trains per day.
- Around 13 buses per day.
- Around 3 flights per day.
However, we recommend checking specific travel dates for your route between Santander and Madrid as scheduled services by train, bus, and flight can vary by season or day of the week.
- Flights mostly depart from Santander Airport and arrive in Madrid Barajas Airport.
- Trains mostly depart from Santander station and arrive in Madrid Chamartín.
- Buses mostly depart from Santander, Estación de Autobuses and arrive in Madrid, Intercambiador de Avenida de América.
- Travel with Alsa, Alsa Supra, FlixBus to go to Madrid by bus.
- Travel with Renfe MD, Renfe INTERCITY, Renfe, Renfe ALVIA to go to Madrid by train.
- Travel with Vueling, CitizenPlane, Iberia to go to Madrid by flight.
- 11 direct buses per day with Alsa, Alsa Supra.
- 3 direct trains per day with Renfe INTERCITY, Renfe ALVIA.
- 3 direct flights per day with CitizenPlane, Iberia.
Travelling from Santander to Madrid: related information
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