The cheapest and fastest buses from Santander to Madrid
Cheapest price on Sep 29
€36
Average ticket price on Sep 29
€49
Fastest journey on Sep 29
5 h
Average journey duration on Sep 29
5 h 21 m
Buses on Sep 29
13
Distance
339 km
The best way to find a cheap bus ticket from Santander to Madrid is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Santander to Madrid will cost around €49 if you buy it on the day, but the cheapest tickets can be found for only €36.
On Tue, Sep 29, we found 13 buses from Santander to Madrid, including 10 direct services.
On Tue, Sep 29 the direct buses cover the 339 km distance in an average of 5 h 21 m but if you time it right, some buses will get you there in just 5 h .
On Tue, Sep 29 the slowest buses will take 5 h 30 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.
Normal5:30 PM5h30Santander, Estación de Autobuses11:00 PMMadrid, Intercambiador de Avenida de América€361One-way0 transfers
Normal · Normal4:00 PM6h45Santander, Estación de Autobuses10:45 PMMadrid, Calle de la Princesa / Paseo de Moret (Moncloa)€371One-way1 transfer
Normal12:00 PM5h30Santander, Estación de Autobuses5:30 PMMadrid, Terminal de autobuses T4 (Aeropuerto de Madrid)€411One-way0 transfers
Normal8:00 AM5h40Santander, Estación de Autobuses1:40 PMMadrid, Terminal de autobuses T4 (Aeropuerto de Madrid)€411One-way0 transfers
Normal12:00 PM5h45Santander, Estación de Autobuses5:45 PMMadrid, Intercambiador de Avenida de América€411One-way0 transfers
Supra Economy3:30 PM5h00Santander, Estación de Autobuses8:30 PMMadrid, Terminal de autobuses T4 (Aeropuerto de Madrid)€481One-way0 transfers
Supra Economy3:30 PM5h15Santander, Estación de Autobuses8:45 PMMadrid, Intercambiador de Avenida de América€471One-way0 transfers
Normal12:00 PM5h30Santander, Estación de Autobuses5:30 PMMadrid, Terminal de autobuses T4 (Aeropuerto de Madrid)€411One-way0 transfers
Supra Economy12:45 AM5h30Santander, Estación de Autobuses6:15 AMMadrid, Terminal de autobuses T4 (Aeropuerto de Madrid)€481One-way0 transfers
Normal5:30 PM5h30Santander, Estación de Autobuses11:00 PMMadrid, Intercambiador de Avenida de América€361One-way0 transfers
Live departures
Santander to Madrid bus times
The table below shows live departures for Santander to Madrid buses for today, Monday, September 28. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
FlixBus · FlixBus | 9:25 AM Santander, Estación de Autobuses | 21h45 | 7:10 AM Madrid, Estación Sur de Autobuses | 1 transfer | |
Normal | 10:30 AM Santander, Estación de Autobuses | 6h15 | 4:45 PM Madrid, Intercambiador de Avenida de América | 0 transfersDirect | |
Normal | 12:00 PM Santander, Estación de Autobuses | 5h30 | 5:30 PM Madrid, Terminal de autobuses T4 (Aeropuerto de Madrid) | 0 transfersDirect | |
Normal | 12:00 PM Santander, Estación de Autobuses | 5h45 | 5:45 PM Madrid, Intercambiador de Avenida de América | 0 transfersDirect | |
Normal | 5:30 PM Santander, Estación de Autobuses | 5h30 | 11:00 PM Madrid, Intercambiador de Avenida de América | 0 transfersDirect | |
FlixBus · FlixBus | 6:50 PM Santander, Estación de Autobuses | 18h30 | 1:20 PM Madrid, Estación Sur de Autobuses | 1 transfer | |
| Tuesday, September 29 | |||||
Supra Economy | 12:45 AM Santander, Estación de Autobuses | 5h45 | 6:30 AM Madrid, Intercambiador de Avenida de América | 0 transfersDirect | |
Supra Economy | 12:45 AM Santander, Estación de Autobuses | 5h30 | 6:15 AM Madrid, Terminal de autobuses T4 (Aeropuerto de Madrid) | 0 transfersDirect | |
Normal | 8:00 AM Santander, Estación de Autobuses | 5h40 | 1:40 PM Madrid, Terminal de autobuses T4 (Aeropuerto de Madrid) | 0 transfersDirect | |
Normal | 8:00 AM Santander, Estación de Autobuses | 5h50 | 1:50 PM Madrid, Intercambiador de Avenida de América | 0 transfersDirect | |
Find all the dates and times for this journey
Compare prices and tickets Santander to Madrid by train, bus, or flight
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Sep 28
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Oct 18
Why should you book Santander to Madrid buses with Omio?
Why book with Omio vs Alsa?
- Compare with other providers: On Omio, you can not only buy tickets for Alsa, but also compare tickets for the likes of Alsa Supra or FlixBus to find the best option for your trip from Santander to Madrid.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Alsa with all available travel options, which are train, bus and flight to ensure you get the best deal for traveling from Santander to Madrid.
Why book with Omio over Checkmybus, Rome2rio or Busbud?
- Compare with other providers: On Omio, you can also compare tickets for the likes of Alsa Supra or FlixBus to find the best option for your trip from Santander to Madrid.
- Multiple modes of transport: Omio allows you to compare travel options including train, bus and flight to find the ideal travel option from Santander to Madrid.
Journey information
Overview: Bus from Santander to Madrid
Buses from Santander to Madrid run on average 13 times per day, taking around 7h 6m. Cheap bus tickets for this journey start at €32 but you can travel from only €7 by train.
There are 11 buses per day. The earliest bus runs at 00:30, the last at 23:45. The fastest bus covers the 339 km distance in 4h 15m.
Distance 339 km |
Average bus duration 7h 6m |
Cheapest ticket price €32 |
Buses per day 13 |
Direct buses 11 |
Fastest bus 4h 15m |
First bus 12:30 AM |
Last bus 11:45 PM |
Cheapest Month Feb |
Cheapest Day Sat |
High Season Jul - Sep |
Low Season Jan - Mar |
Busiest Day Fri |
Least Busy Day Sun |
Best time to book 91 days |
Bus providers: Alsa, FlixBus, Alsa Supra from Santander to MadridYou can travel by bus between Santander to Madrid with Alsa, FlixBus, Alsa Supra for as low as €7. When you search for schedules and tickets, Omio will show you the best journey
Alsa
FlixBus
Alsa Supra
FAQs: Bus from Santander to Madrid
Find answers to the most common questions about traveling from Santander to Madrid by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Madrid, this guide helps you travel smarter and with confidence.

- Alsa
- Assistance
- Priority boarding
- Accessible seating.
- Alsa Supra
- Assistance
- Priority boarding
- Accessible restrooms.
- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
- Alsa
- You can cancel your ticket up to 48 hours before departure for a partial refund. Changes allowed for a fee.
- Alsa Supra
- You can cancel your ticket up to 48 hours before departure for a partial refund. Within 48 hours, a fee applies.
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
- Alsa
- One carry-on bag up to 10kg and one checked bag up to 25kg.
- Alsa Supra
- One carry-on bag up to 10kg and one checked bag up to 25kg.
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
- Alsa
- Additional luggage can be purchased for a fee.
- Alsa Supra
- Additional luggage can be purchased for a fee.
- FlixBus
- Additional luggage can be purchased for a fee.
- Alsa
- Small pets allowed in carriers
- larger pets must travel in the hold.
- Alsa Supra
- Small pets allowed in carriers
- guide dogs travel for free.
- FlixBus
- Small pets in carriers allowed
- guide dogs travel for free.
popular bus stations
Popular bus stations from Santander to Madrid
Most Santander to Madrid buses use the Santander, Estación de Autobuses to Madrid, Avenida de América station pair, with some services arriving at Madrid, Terminal de autobuses T4 (Aeropuerto de Madrid). Use this guide to compare Santander and Madrid bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Which Madrid station do buses from Santander arrive at?
Getting to Madrid, Avenida de América from Madrid city centre
Madrid, Avenida de América is 3 km from Madrid city centre. Public transport options include:
Madrid, Avenida de América bus station facilities and services
Madrid, Avenida de América has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, and Ticket Office.
Food and drink
Food options include: Cafetería de la estación (in the station), Restaurante El Rincón (0.5 km), La Vaca Argentina (0.7 km).
Wi-Fi and ATMs
Free Wi-Fi. ATMs are located near the main entrance and on the second floor.
Tickets and information
Ticket office support is available at Madrid, Avenida de América.
Parking, taxis and toilets
Available at Madrid, Avenida de América: Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Madrid, Avenida de América: Elevators, ramps.
Getting to Madrid, Terminal de autobuses T4 (Aeropuerto de Madrid) from Madrid city centre
Madrid, Terminal de autobuses T4 (Aeropuerto de Madrid) is 12 km from Madrid city centre. Public transport options include:
Madrid, Terminal de autobuses T4 (Aeropuerto de Madrid) bus station facilities and services
Madrid, Terminal de autobuses T4 (Aeropuerto de Madrid) has practical services for this route, including Dining, ATM, Accessibility, WC, Shower, and Ticket Office.
Food and drink
Food options include: Rodilla, Mahoudrid
Wi-Fi and ATMs
ATMs are aTMs located throughout T4, major cards accepted .
Tickets and information
Ticket office support is available at Madrid, Terminal de autobuses T4 (Aeropuerto de Madrid).
Parking, taxis and toilets
Available at Madrid, Terminal de autobuses T4 (Aeropuerto de Madrid): WC.
Accessibility
Accessibility facilities are available at Madrid, Terminal de autobuses T4 (Aeropuerto de Madrid): Step-free access, elevators, accessible toilets.
Getting to Madrid, Estación Sur de Autobuses from Madrid city centre
Madrid, Estación Sur de Autobuses is 3 km from Madrid city centre. Public transport options include:
Madrid, Estación Sur de Autobuses bus station facilities and services
Madrid, Estación Sur de Autobuses has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, and Ticket Office.
Food and drink
Food options include: Cafetería de la estación (in the station), Restaurante El Brillante (0.5 km), La Taberna de Domínguez (0.7 km).
Wi-Fi and ATMs
Free Wi-Fi. ATMs are located near the main entrance and in the waiting area.
Tickets and information
Ticket office support is available at Madrid, Estación Sur de Autobuses.
Parking, taxis and toilets
Available at Madrid, Estación Sur de Autobuses: Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Madrid, Estación Sur de Autobuses: Elevators, ramps.
More options for your journey from Santander to Madrid
Here are some other resources that might have the information you need

