The cheapest and fastest buses from Santander to Madrid
Cheapest price
€118
Average price
€138
Fastest journey
18 h 30 m
Average duration
20 h 8 m
Buses per day
2
Distance
339 km
The best way to find a cheap bus ticket from Santander to Madrid is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Santander to Madrid will cost around €138 if you buy it on the day, but the cheapest tickets can be found for only €118.
It's difficult to get from Santander to Madrid without transferring at least once.
FlixBus · FlixBus6:50 PM18h30Santander, Estación de Autobuses1:20 PMMadrid, Estación Sur de Autobuses€1181One-way1 transfer
FlixBus · FlixBus9:25 AM21h45Santander, Estación de Autobuses7:10 AMMadrid, Estación Sur de Autobuses€1591One-way1 transfer
FlixBus · FlixBus6:50 PM18h30Santander, Estación de Autobuses1:20 PMMadrid, Estación Sur de Autobuses€1181One-way1 transfer
FlixBus · FlixBus9:25 AM21h45Santander, Estación de Autobuses7:10 AMMadrid, Estación Sur de Autobuses€1591One-way1 transfer
Travel Information
Compare bus, train, and flight for Santander to Madrid
Omio recommends booking the train as it is the most popular option from Santander to Madrid among Omio's users. If you are prioritising price take the train with prices starting from €16. For those with little time consider booking a flight which can get you there in 2h 41m. In case you are seeking to minimise your carbon footprint the train is your best bet as it emits only 0.1 - 0.3kg. The ticket price range depends on the travel mode: a train costs an average of €16, and a flight costs an average of €49.
Distance: 339 km
Compare bus with
| Bus | Most popular Train | Flight |
|---|---|---|
€54 Average price | €31 Average price Cheapest | €254 Average price |
6h 22m Average total duration 5h 52m Onboard + 30m Additional time* | 4h 47m Average total duration 4h 17m Onboard + 30m Additional time* | 5h 41m Average total duration Fastest 2h 41m Onboard + 3h 0m Additional time* |
0.3 - 0.8kg CO2 emissions | 0.1 - 0.3kg CO2 emissions Lowest | 1.0 - 2.0kg CO2 emissions |
![]() Most popular bus company | ![]() Most popular train company | ![]() Most popular airline |
Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
Live departures
Santander to Madrid bus times
The table below shows live departures for Santander to Madrid buses for tomorrow, Saturday, May 16. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
FlixBus · FlixBus | 9:25 AM Santander, Estación de Autobuses | 21h45 | 7:10 AM Madrid, Estación Sur de Autobuses | 1 transfer | |
FlixBus · FlixBus | 6:50 PM Santander, Estación de Autobuses | 18h30 | 1:20 PM Madrid, Estación Sur de Autobuses | 1 transfer | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Santander to Madrid by bus, train, or flight
Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
May 16
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Why should you book Santander to Madrid buses with Omio?
Why book with Omio vs Alsa?
- Compare with other providers: On Omio, you can not only buy tickets for Alsa, but also compare tickets for the likes of Alsa Supra or FlixBus to find the best option for your trip from Santander to Madrid.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Alsa with all available travel options, which are bus, train and flight to ensure you get the best deal for traveling from Santander to Madrid.
Why book with Omio over Checkmybus, Rome2rio or Busbud?
- Compare with other providers: On Omio, you can also compare tickets for the likes of Alsa Supra or FlixBus to find the best option for your trip from Santander to Madrid.
- Multiple modes of transport: Omio allows you to compare travel options including bus, train and flight to find the ideal travel option from Santander to Madrid.
Journey information
Overview: Bus from Santander to Madrid
Buses from Santander to Madrid run on average 15 times per day, taking around 5h 52m. Cheap bus tickets for this journey start at €33 but you can travel from only €16 by train.
There are 12 buses per day. The earliest bus runs at 00:30, the last at 23:45. The fastest bus covers the 339 km distance in 5h 15m.
Distance 339 km |
Average bus duration 5h 52m |
Cheapest ticket price €33 |
Buses per day 15 |
Direct buses 12 |
Fastest bus 5h 15m |
First bus 12:30 AM |
Last bus 11:45 PM |
Cheapest Month Feb |
Cheapest Day Sat |
High Season Jul - Sep |
Low Season Jan - Mar |
Busiest Day Wed |
Least Busy Day Sun |
Best time to book 91 days |
Bus providers: Alsa, Alsa Supra, BlaBlaCar, FlixBus from Santander to MadridYou can travel by bus between Santander to Madrid with Alsa, Alsa Supra, BlaBlaCar, FlixBus for as low as €16. When you search for schedules and tickets, Omio will show you the best journey
Alsa
Alsa Supra
FlixBus
BlaBlaCar
FAQs: Bus from Santander to Madrid
Find answers to the most common questions about traveling from Santander to Madrid by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Madrid, this guide helps you travel smarter and with confidence.

- Alsa
- Assistance
- Priority boarding
- Accessible seating.
- Alsa Supra
- Assistance
- Priority boarding
- Accessible restrooms.
- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
- Alsa
- You can cancel your ticket up to 48 hours before departure for a partial refund. Changes allowed for a fee.
- Alsa Supra
- You can cancel your ticket up to 48 hours before departure for a partial refund. Within 48 hours, a fee applies.
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
- Alsa
- One carry-on bag up to 10kg and one checked bag up to 25kg.
- Alsa Supra
- One carry-on bag up to 10kg and one checked bag up to 25kg.
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
- Alsa
- Additional luggage can be purchased for a fee.
- Alsa Supra
- Additional luggage can be purchased for a fee.
- FlixBus
- Additional luggage can be purchased for a fee.
- Alsa
- Small pets allowed in carriers
- larger pets must travel in the hold.
- Alsa Supra
- Small pets allowed in carriers
- guide dogs travel for free.
- FlixBus
- Small pets in carriers allowed
- guide dogs travel for free.
popular bus stations
Popular bus stations from Santander to Madrid
- 06:00-23:00
- Free Wi-Fi
- Cafetería de la estación (in the station)
- Restaurante El Rincón (0.5 km)
- La Vaca Argentina (0.7 km).
- Available outside the main entrance.
- Elevators, ramps
- Available in the station.
- Bus: 200, 114, 115, 122 Metro: 4, 6, 7, 9
- 06:00-23:00
- Rodilla, Mahoudrid
- Step-free access, elevators, accessible toilets
- Located inside the terminal, well-signposted, accessible, and generally clean
- No public showers in the bus station area; showers available in airport lounges (approx. €15-€30 for lounge access)
- Metro Line 8, Aeropuerto T4, 12 km
- 06:00-23:00
- Free Wi-Fi
- Cafetería de la estación (in the station)
- Restaurante El Brillante (0.5 km)
- La Taberna de Domínguez (0.7 km).
- Available outside the main entrance.
- Elevators, ramps
- Available in the station.
- Bus: 8, 102, 148 Metro: L6 Train: C1, C5
Most popular bus connections from Santander
More options for your journey from Santander to Madrid
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