The cheapest and fastest buses from Madrid to Brussels
Cheapest price
€109
Average price
€132
Fastest journey
20 h 40 m
Average duration
21 h 49 m
Buses per day
6
Distance
1316 km
The best way to find a cheap bus ticket from Madrid to Brussels is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Madrid to Brussels will cost around €132 if you buy it on the day, but the cheapest tickets can be found for only €109.
It's difficult to get from Madrid to Brussels without transferring at least once.
3162 · 50321
3160 · 50331
FlixBus · FlixBus · FlixBus
FlixBus · FlixBus · FlixBus
FlixBus · FlixBus
3162 · 50321
FlixBus · FlixBus
3160 · 50331
FlixBus · FlixBus
FlixBus · FlixBus · FlixBusTravel Information
Compare train, bus, and flight for Madrid to Brussels
Omio recommends booking the flight as it is the most popular option from Madrid to Brussels among Omio's users. If you are prioritising price take the bus with prices starting from €43. For those with little time consider booking a flight which can get you there in 2h 58m. In case you are seeking to minimise your carbon footprint the bus is your best bet as it emits only 1.3 - 3.3kg. The ticket price range depends on the travel mode: a bus costs an average of €43, and a train costs an average of €377.
Distance: 1316 km
Compare bus with
| Bus | Most popular Flight | Train |
|---|---|---|
€115 Average price Cheapest | €278 Average price | €386 Average price |
22h 15m Average total duration 21h 45m Onboard + 30m Additional time* | 5h 58m Average total duration Fastest 2h 58m Onboard + 3h 0m Additional time* | 15h 45m Average total duration 15h 15m Onboard + 30m Additional time* |
1.3 - 3.3kg CO2 emissions Lowest | 3.9 - 7.9kg CO2 emissions | - CO2 emissions |
Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
Live departures
Madrid to Brussels bus times
The table below shows live departures for Madrid to Brussels buses for tomorrow, Monday, November 10. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
FlixBus · FlixBus · FlixBus | 3:40 PM Madrid, Estación Sur de Autobuses | 24h35 | 4:15 PM Brussels, Brussels South (Gare du Midi) | 2 transfers | |
3162 · 50321 | 5:35 PM Madrid, Estación Sur de Autobuses | 20h40 | 2:15 PM Brussels, Brussels South (Gare du Midi) | 1 transfer | |
FlixBus · FlixBus | 7:25 PM Madrid, Estación Sur de Autobuses | 21h30 | 4:55 PM Brussels, Brussels South (Gare du Midi) | 1 transfer | |
FlixBus · FlixBus · FlixBus | 7:50 PM Madrid, Estación Sur de Autobuses | 27h45 | 11:35 PM Brussels, Brussels South (Gare du Midi) | 2 transfers | |
FlixBus · FlixBus | 7:50 PM Madrid, Terminal de autobuses T4 (Aeropuerto de Madrid) | 21h05 | 4:55 PM Brussels, Brussels South (Gare du Midi) | 1 transfer | |
3160 · 50331 | 9:30 PM Madrid, Estación Sur de Autobuses | 21h15 | 6:45 PM Brussels, Brussels South (Gare du Midi) | 1 transfer | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Madrid to Brussels by train, bus, or flight
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Journey information
Overview: Bus from Madrid to Brussels
Buses from Madrid to Brussels run on average 12 times per day, taking around 21h 45m. Cheap bus tickets for this journey start at €43 if you book in advance.
The earliest bus runs at 00:25, the last at 23:55. The fastest bus covers the 1316 km distance in 20h 40m.
Distance 1316 km |
Average bus duration 21h 45m |
Cheapest ticket price €43 |
Buses per day 12 |
Fastest bus 20h 40m |
First bus 00:25 |
Last bus 23:55 |
Bus providers: BlaBlaCar Bus, FlixBus, Alsa, Infobus, Empresa Municipal de Transportes from Madrid to BrusselsYou can travel by bus between Madrid to Brussels with BlaBlaCar Bus, FlixBus, Alsa, Infobus, Empresa Municipal de Transportes for as low as €43. When you search for schedules and tickets, Omio will show you the best journey
FlixBus
Alsa
Infobus
BlaBlaCar Bus
Empresa Municipal de Transportes
FAQs: Bus from Madrid to Brussels
Find answers to the most common questions about traveling from Madrid to Brussels by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Brussels, this guide helps you travel smarter and with confidence.

When departing from Madrid, you have various coach station options to start your journey from including Madrid, Estación Sur de Autobuses, Madrid, Aeropuerto Barajas T4 and Madrid, Estación Sur/Gare routière Méndez Alvaro - 83. When arriving in Brussels, you can end your route in coach stations like Brussels, Brussels South (Gare du Midi), Bruxelles, Gare du Nord and Zaventem, Brussels Airport Leopoldlaan (Parking P16).
Passengers board the coach most frequently from Madrid, Estación Sur de Autobuses, which is located around 3.1 miles (5 km) away from the city centre, and they get off the coach at Brussels, Brussels South (Gare du Midi), located 2.7 miles (4.3 km) away from the city centre.
popular bus stations
Popular bus stations from Madrid to Brussels
- 06:00-23:00
- Free Wi-Fi
- Cafetería de la estación (in the station)
- Restaurante El Brillante (0.5 km)
- La Taberna de Domínguez (0.7 km).
- Available outside the main entrance.
- Elevators, ramps
- Available in the station.
- Bus: 8, 102, 148 Metro: L6 Train: C1, C5
- 06:00-23:59
- Free Wi-Fi
- Cafeteria Noord (in the station)
- Quick Brussels Noord (in the station)
- Le Pain Quotidien (0.5 km).
- Available outside the main entrance.
- Elevators, ramps
- Available in the station.
- Bus: 14, 57, 58 Metro: 2, 6 Train: IC, S1, S2
- 06:00-23:00
- Free Wi-Fi
- Cafeteria Midi (in the station)
- Belgian Bites (in the station)
- Fritland Express (0.5 km).
- Available outside the main entrance.
- Elevators, ramps
- Available in the station.
- Bus: 27, 49, 50, 78 Metro: 2, 6 Train: IC, S, Thalys, Eurostar
Most popular bus connections from Madrid
More options for your journey from Madrid to Brussels
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