The cheapest and fastest buses from Pisa Centrale to Rome
Cheapest price
€16
Average price
€22
Fastest journey
4 h 14 m
Average duration
5 h 1 m
Buses per day
9
Distance
264 km
The best way to find a cheap bus ticket from Pisa Centrale to Rome is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Pisa Centrale to Rome will cost around €22 if you buy it on the day, but the cheapest tickets can be found for only €16.
Of the 9 buses that leave Pisa Centrale for Rome on Tue, May 05, 6 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Tue, May 05 the direct buses cover the 264 km distance in an average of 5 h 1 m but if you time it right, some buses will get you there in just 4 h 14 m .
On Tue, May 05 the slowest buses will take 5 h 30 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.
FlixBus1:25 PM5h10Pisa, Via delle Fiamme Gialle (Park Pietrasantina)6:35 PMRoma, Autostazione Tiburtina€161One-way0 transfers
2078:20 AM6h00Pisa, Via delle Fiamme Gialle (Park Pietrasantina)2:20 PMRoma, Autostazione Tiburtina€181One-way0 transfers
2078:55 AM5h25Lucca, Stazione FS2:20 PMRoma, Autostazione Tiburtina€181One-way0 transfers
FlixBus12:25 AM5h30Pisa, Via delle Fiamme Gialle (Park Pietrasantina)5:55 AMRoma, Autostazione Tiburtina€191One-way0 transfers
FlixBus · FlixBus4:45 AM6h40Pisa, Via delle Fiamme Gialle (Park Pietrasantina)11:25 AMRoma, Autostazione Tiburtina€221One-way1 transfer
7:45 PM4h14Pisa, Via delle Fiamme Gialle (Park Pietrasantina)11:59 PMRoma, Autostazione Tiburtina€311One-way0 transfers
FlixBus6:05 AM4h45Pisa, Aeroporto Parcheggio Aurelia10:50 AMRoma, Autostazione Tiburtina€261One-way0 transfers
FlixBus1:25 PM5h10Pisa, Via delle Fiamme Gialle (Park Pietrasantina)6:35 PMRoma, Autostazione Tiburtina€161One-way0 transfers
2078:55 AM5h25Lucca, Stazione FS2:20 PMRoma, Autostazione Tiburtina€181One-way0 transfers
FlixBus12:25 AM5h30Pisa, Via delle Fiamme Gialle (Park Pietrasantina)5:55 AMRoma, Autostazione Tiburtina€191One-way0 transfers
Travel Information
Compare train and bus for Pisa Centrale to Rome
Omio recommends booking the train as it is the most popular option from Pisa Centrale to Rome among Omio's users. If you are prioritising price take the bus with prices starting from €10. For those with little time consider booking a train which can get you there in 3h 5m. The ticket price range depends on the travel mode: a bus costs an average of €10, and a train costs an average of €13.
Distance: 264 km
Compare bus with
| Bus | Most popular Train |
|---|---|
€18 Average price Cheapest | €23 Average price |
5h 24m Average total duration 4h 54m Onboard + 30m Additional time* | 3h 35m Average total duration Fastest 3h 5m Onboard + 30m Additional time* |
![]() Most popular bus company | ![]() Most popular train company |
Direct Options | Direct Options |
Live departures
Pisa Centrale to Rome bus times
The table below shows live departures for Pisa Centrale to Rome buses for tomorrow, Tuesday, May 5. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
FlixBus | 12:25 AM Pisa, Via delle Fiamme Gialle (Park Pietrasantina) | 5h30 | 5:55 AM Roma, Autostazione Tiburtina | 0 transfersDirect | |
FlixBus · FlixBus | 4:45 AM Pisa, Via delle Fiamme Gialle (Park Pietrasantina) | 6h40 | 11:25 AM Roma, Autostazione Tiburtina | 1 transfer | |
FlixBus | 6:05 AM Pisa, Aeroporto Parcheggio Aurelia | 4h45 | 10:50 AM Roma, Autostazione Tiburtina | 0 transfersDirect | |
FlixBus · FlixBus | 7:15 AM Pisa, Via delle Fiamme Gialle (Park Pietrasantina) | 6h05 | 1:20 PM Roma, Autostazione Tiburtina | 1 transfer | |
207 | 8:20 AM Pisa, Via delle Fiamme Gialle (Park Pietrasantina) | 6h00 | 2:20 PM Roma, Autostazione Tiburtina | 0 transfersDirect | |
207 | 8:55 AM Lucca, Stazione FS | 5h25 | 2:20 PM Roma, Autostazione Tiburtina | 0 transfersDirect | |
FlixBus | 1:25 PM Pisa, Via delle Fiamme Gialle (Park Pietrasantina) | 5h10 | 6:35 PM Roma, Autostazione Tiburtina | 0 transfersDirect | |
FlixBus · FlixBus | 5:10 PM Pisa, Via delle Fiamme Gialle (Park Pietrasantina) | 5h50 | 11:00 PM Roma, Autostazione Tiburtina | 1 transfer | |
![]() | 7:45 PM Pisa, Via delle Fiamme Gialle (Park Pietrasantina) | 4h14 | 11:59 PM Roma, Autostazione Tiburtina | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Pisa Centrale to Rome by train or bus
Compare train and bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
May 05
May 06
May 07
May 08
May 09
May 10
May 11
May 12
May 13
May 14
May 15
May 16
May 17
May 18
May 19
May 20
May 21
May 22
May 23
May 24
May 25
May 26
May 27
May 28
May 29
May 30
May 31
Jun 01
Why should you book Pisa Centrale to Rome buses with Omio?
Why book with Omio vs FlixBus?
- Compare with other providers: On Omio, you can not only buy tickets for FlixBus, but also compare tickets for the likes of Marino Autolinee or Busitalia to find the best option for your trip from Pisa Centrale to Rome.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare FlixBus with all available travel options, which are train and bus to ensure you get the best deal for traveling from Pisa Centrale to Rome.
Why book with Omio over Wanderu, Trainline or Checkmybus?
- Compare with other providers: On Omio, you can also compare tickets for the likes of Marino Autolinee or Busitalia to find the best option for your trip from Pisa Centrale to Rome.
- Multiple modes of transport: Omio allows you to compare travel options including train and bus to find the ideal travel option from Pisa Centrale to Rome.
Journey information
Overview: Bus from Pisa Centrale to Rome
Buses from Pisa Centrale to Rome run on average 10 times per day, taking around 4h 54m. Cheap bus tickets for this journey start at €10 if you book in advance.
There are 8 buses per day. The earliest bus runs at 05:00, the last at 23:25. The fastest bus covers the 264 km distance in 4h 14m.
Distance 264 km |
Average bus duration 4h 54m |
Cheapest ticket price €10 |
Buses per day 10 |
Direct buses 8 |
Fastest bus 4h 14m |
First bus 5:00 AM |
Last bus 11:25 PM |
Cheapest Month Sep |
Cheapest Day Sat |
High Season Jul - Sep |
Low Season Jan - Mar |
Busiest Day Thu |
Least Busy Day Sat |
Bus providers: FlixBus, Marino Autolinee, BlaBlaCar, Busitalia from Pisa Centrale to RomeYou can travel by bus between Pisa Centrale to Rome with FlixBus, Marino Autolinee, BlaBlaCar, Busitalia for as low as €10. When you search for schedules and tickets, Omio will show you the best journey
FlixBus
Marino Autolinee
Busitalia
BlaBlaCar
FAQs: Bus from Pisa Centrale to Rome
Find answers to the most common questions about traveling from Pisa Centrale to Rome by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Rome, this guide helps you travel smarter and with confidence.

- Marino Autolinee
- Assistance
- Priority seating
- Accessible restrooms.
- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
- Busitalia
- People with disabilities or reduced mobility have the right to free transport of their folding wheelchair or mobility aids in the luggage compartment, and assistance dogs and companions travel free of charge if continuous assistance is required.
- Marino Autolinee
- You can cancel your ticket up to 24 hours before departure for a full refund. Cancellations within 24 hours incur a 50% fee.
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
- Busitalia
- Vouchers are issued for cancellations made before departure, which can be used for future purchases within one year.
- Marino Autolinee
- One carry-on bag up to 10kg (55x40x20 cm) and one checked bag up to 20kg (80x50x30 cm).
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
- Busitalia
- One piece of hand luggage (50x30x25 cm, max 10 kg) and one piece of hold luggage (80x50x30 cm, max 20 kg) are included free of charge.
- Marino Autolinee
- 10€ per additional bag up to 20 kg.
- FlixBus
- Additional luggage can be purchased for a fee.
- Busitalia
- An additional hold luggage item (80x50x30 cm, max 20 kg) or special baggage (total volume not exceeding 240 cm, max 30 kg) can be purchased.
- Marino Autolinee
- Small pets allowed in carriers
- larger pets must be leashed and muzzled.
- FlixBus
- Small pets in carriers allowed
- guide dogs travel for free.
- Busitalia
- Small pets (cats or small dogs) are allowed free of charge if held and not disturbing other customers
- medium and large dogs require a ticket and must have a muzzle and leash.
popular bus stations
Popular bus stations from Pisa Centrale to Rome
- 06:00-23:00
- Free Wi-Fi
- Ristorante Italiano (in the station)
- Fast Food Express (in the station)
- Caffè del Terminal (in the station).
- Available outside the arrivals terminal.
- Elevators, ramps
- Available in the station.
- Bus: 520, 720 Train: Leonardo Express
More options for your journey from Pisa Centrale to Rome
Here are some other resources that might have the information you need

