The cheapest and fastest buses from Milan Centrale to Siena
Cheapest price
€9
Average price
€12
Fastest journey
5 h 40 m
Average duration
6 h 18 m
Buses per day
5
Distance
294 km
The best way to find a cheap bus ticket from Milan Centrale to Siena is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Milan Centrale to Siena will cost around €12 if you buy it on the day, but the cheapest tickets can be found for only €9.
Of the 5 buses that leave Milan Centrale for Siena on Wed, Feb 25, 5 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Wed, Feb 25 the direct buses cover the 294 km distance in an average of 6 h 18 m but if you time it right, some buses will get you there in just 5 h 40 m .
On Wed, Feb 25 the slowest buses will take 7 h 30 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.










Travel Information
Compare bus and train for Milan Centrale to Siena
Omio recommends booking the train as it is the most popular option from Milan Centrale to Siena among Omio's users. If you are prioritising price take the bus with prices starting from €8. For those with little time consider booking a train which can get you there in 4h 54m. The ticket price range depends on the travel mode: a bus costs an average of €8, and a train costs an average of €26.
Distance: 294 km
Compare bus with
| Bus | Most popular Train |
|---|---|
€15 Average price Cheapest | €34 Average price |
5h 37m Average total duration 5h 7m Onboard + 30m Additional time* | 5h 24m Average total duration Fastest 4h 54m Onboard + 30m Additional time* |
![]() Most popular bus company | ![]() Most popular train company |
Direct Options | Direct Options |
Live departures
Milan Centrale to Siena bus times
The table below shows live departures for Milan Centrale to Siena buses for today, Tuesday, February 24. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
FlixBus | 7:15 AM Milano, Autostazione Lampugnano | 7h25 | 2:40 PM Siena, Stazione FS (Piazzale Carlo Rosselli) | 0 transfersDirect | |
FlixBus | 7:20 AM Milano, Autostazione Lampugnano | 6h35 | 1:55 PM Siena, Stazione FS (Piazzale Carlo Rosselli) | 0 transfersDirect | |
FlixBus | 8:05 AM Assago, Viale Milanofiori (Assago M2) | 5h50 | 1:55 PM Siena, Stazione FS (Piazzale Carlo Rosselli) | 0 transfersDirect | |
2125 | 9:40 AM Milano, Autostazione Lampugnano | 5h40 | 3:20 PM Siena, Stazione FS (Piazzale Carlo Rosselli) | 0 transfersDirect | |
3811 | 10:30 AM Milano, Autostazione Lampugnano | 6h20 | 4:50 PM Siena, Stazione FS (Piazzale Carlo Rosselli) | 0 transfersDirect | |
FlixBus | 2:30 PM Milano, Autostazione Lampugnano | 5h45 | 8:15 PM Siena, Stazione FS (Piazzale Carlo Rosselli) | 0 transfersDirect | |
FlixBus | 3:20 PM Milano, Autostazione Lampugnano | 6h00 | 9:20 PM Siena, Stazione FS (Piazzale Carlo Rosselli) | 0 transfersDirect | |
FlixBus | 4:05 PM Milano, San Donato - Settore B (Viale Giuseppe Impastato) | 5h15 | 9:20 PM Siena, Stazione FS (Piazzale Carlo Rosselli) | 0 transfersDirect | |
| Wednesday, February 25 | |||||
![]() | 5:00 AM Milan Centrale | 6h05 | 11:05 AM Siena | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Milan Centrale to Siena by bus or train
Compare bus and train prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Feb 25
Feb 26
Feb 27
Feb 28
Mar 01
Mar 02
Mar 03
Mar 04
Mar 05
Mar 06
Mar 07
Mar 08
Mar 09
Mar 10
Why should you book Milan Centrale to Siena buses with Omio?
Why book with Omio vs FlixBus?
- Compare with other providers: On Omio, you can not only buy tickets for FlixBus, but also compare tickets for the likes of Itabus to find the best option for your trip from Milan Centrale to Siena.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare FlixBus with all available travel options, which are bus and train to ensure you get the best deal for traveling from Milan Centrale to Siena.
Why book with Omio over Wanderu, Trainline or Checkmybus?
- Compare with other providers: On Omio, you can also compare tickets for the likes of Itabus to find the best option for your trip from Milan Centrale to Siena.
- Multiple modes of transport: Omio allows you to compare travel options including bus and train to find the ideal travel option from Milan Centrale to Siena.
Journey information
Overview: Bus from Milan Centrale to Siena
Buses from Milan Centrale to Siena run on average 18 times per day, taking around 5h 7m. Cheap bus tickets for this journey start at €8 if you book in advance.
There are 16 buses per day. The earliest bus runs at 05:00, the last at 21:40. The fastest bus covers the 294 km distance in 5h 30m.
Distance 294 km |
Average bus duration 5h 7m |
Cheapest ticket price €8 |
Buses per day 18 |
Direct buses 16 |
Fastest bus 5h 30m |
First bus 05:00 |
Last bus 21:40 |
Bus providers: FlixBus, BlaBlaCar, Itabus from Milan Centrale to SienaYou can travel by bus between Milan Centrale to Siena with FlixBus, BlaBlaCar, Itabus for as low as €8. When you search for schedules and tickets, Omio will show you the best journey
FlixBus
Itabus
BlaBlaCar
FAQs: Bus from Milan Centrale to Siena
Find answers to the most common questions about traveling from Milan Centrale to Siena by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Siena, this guide helps you travel smarter and with confidence.

- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
- Itabus
- Assistance
- Dedicated seating areas
- Accessible restrooms.
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
- Itabus
- You can cancel your ticket up to 24 hours before departure for a partial refund. Changes allowed for a fee.
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
- Itabus
- One carry-on bag up to 10kg and one checked bag up to 20kg.
- FlixBus
- Additional luggage can be purchased for a fee.
- Itabus
- 5€ per additional bag.
- FlixBus
- Small pets in carriers allowed
- guide dogs travel for free.
- Itabus
- Small pets allowed in carriers
- larger pets must be leashed and muzzled.
popular bus stations
Popular bus stations from Milan Centrale to Siena
Most popular bus connections from Milan Centrale
More options for your journey from Milan Centrale to Siena
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