The cheapest and fastest buses from Siena to Milan
Cheapest price
€10
Average price
€24
Fastest journey
3 h 20 m
Average duration
3 h 50 m
Buses per day
22
Distance
293 km
The best way to find a cheap bus ticket from Siena to Milan is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Siena to Milan will cost around €24 if you buy it on the day, but the cheapest tickets can be found for only €10.
Of the 22 buses that leave Siena for Milan on Sat, Mar 21, 21 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Sat, Mar 21 the direct buses cover the 293 km distance in an average of 3 h 50 m but if you time it right, some buses will get you there in just 3 h 20 m .
On Sat, Mar 21 the slowest buses will take 4 h 30 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.
2490
2126
FlixBus
FlixBus
FlixBus



FlixBusTravel Information
Compare bus, train, and flight for Siena to Milan
Omio recommends booking the bus as it is the most popular option from Siena to Milan among Omio's users. If you are prioritising price take the bus with prices starting from €8. For those with little time consider booking a train which can get you there in 4h 1m. In case you are seeking to minimise your carbon footprint the train is your best bet as it emits only 0.1 - 0.3kg. The ticket price range depends on the travel mode: a bus costs an average of €8, and a flight costs an average of €103.
Distance: 293 km
Compare bus with
Most popular Bus | Train | Flight |
|---|---|---|
€16 Average price Cheapest | €36 Average price | €105 Average price |
6h 23m Average total duration 5h 53m Onboard + 30m Additional time* | 4h 31m Average total duration Fastest 4h 1m Onboard + 30m Additional time* | 9h 22m Average total duration 6h 22m Onboard + 3h 0m Additional time* |
0.3 - 0.7kg CO2 emissions | 0.1 - 0.3kg CO2 emissions Lowest | - CO2 emissions |
Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
Live departures
Siena to Milan bus times
The table below shows live departures for Siena to Milan buses for today, Friday, March 20. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
FlixBus | 1:25 PM Siena, Stazione FS (Piazzale Carlo Rosselli) | 7h20 | 8:45 PM Milano, Autostazione Lampugnano | 0 transfersDirect | |
FlixBus | 1:51 PM Siena, Siena/Viale Pietro Toselli | 6h49 | 8:40 PM Milano, Autostazione Lampugnano | 0 transfersDirect | |
FlixBus | 2:05 PM Siena, Stazione FS (Piazzale Carlo Rosselli) | 6h35 | 8:40 PM Milano, Autostazione Lampugnano | 0 transfersDirect | |
FlixBus | 3:05 PM Siena, Stazione FS (Piazzale Carlo Rosselli) | 4h50 | 7:55 PM Milano, San Donato - Settore B (Viale Giuseppe Impastato) | 0 transfersDirect | |
2490 | 5:35 PM Siena, Stazione FS (Piazzale Carlo Rosselli) | 5h14 | 10:49 PM Milano, San Donato - Settore B (Viale Giuseppe Impastato) | 0 transfersDirect | |
FlixBus | 5:40 PM Siena, Stazione FS (Piazzale Carlo Rosselli) | 5h19 | 10:59 PM Milano, Autostazione Lampugnano | 0 transfersDirect | |
FlixBus | 11:45 PM Siena, Stazione FS (Piazzale Carlo Rosselli) | 4h30 | 4:15 AM Milano, San Donato - Settore B (Viale Giuseppe Impastato) | 0 transfersDirect | |
FlixBus | 11:45 PM Siena, Stazione FS (Piazzale Carlo Rosselli) | 5h10 | 4:55 AM Milano, Autostazione Lampugnano | 0 transfersDirect | |
| Saturday, March 21 | |||||
2494 | 12:05 AM Siena, Stazione FS (Piazzale Carlo Rosselli) | 5h50 | 5:55 AM Milano, Autostazione Lampugnano | 0 transfersDirect | |
FlixBus | 5:10 AM Siena, Stazione FS (Piazzale Carlo Rosselli) | 5h45 | 10:55 AM Milano, Autostazione Lampugnano | 0 transfersDirect | |
FlixBus | 5:40 AM Siena, Stazione FS (Piazzale Carlo Rosselli) | 4h50 | 10:30 AM Milano, San Donato - Settore B (Viale Giuseppe Impastato) | 0 transfersDirect | |
FlixBus | 6:50 AM Siena, Stazione FS (Piazzale Carlo Rosselli) | 5h55 | 12:45 PM Milano, Autostazione Lampugnano | 0 transfersDirect | |
FlixBus | 8:20 AM Siena, Stazione FS (Piazzale Carlo Rosselli) | 6h00 | 2:20 PM Milano, Autostazione Lampugnano | 0 transfersDirect | |
FlixBus | 8:20 AM Siena, Stazione FS (Piazzale Carlo Rosselli) | 5h15 | 1:35 PM Milano, San Donato - Settore B (Viale Giuseppe Impastato) | 0 transfersDirect | |
2126 | 9:55 AM Siena, Stazione FS (Piazzale Carlo Rosselli) | 5h45 | 3:40 PM Milano, Autostazione Lampugnano | 0 transfersDirect | |
FlixBus | 10:30 AM Siena, Stazione FS (Piazzale Carlo Rosselli) | 7h25 | 5:55 PM Milano, Autostazione Lampugnano | 0 transfersDirect | |
FlixBus | 11:15 AM Siena, Stazione FS (Piazzale Carlo Rosselli) | 5h40 | 4:55 PM Milano, Autostazione Lampugnano | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Siena to Milan by bus, train, or flight
Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Mar 20
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Mar 30
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Apr 01
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Apr 09
Why should you book Siena to Milan buses with Omio?
Why book with Omio vs FlixBus?
- Compare with other providers: On Omio, you can not only buy tickets for FlixBus, but also compare tickets for the likes of Itabus or Curcio Viaggi to find the best option for your trip from Siena to Milan.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare FlixBus with all available travel options, which are bus, train and flight to ensure you get the best deal for traveling from Siena to Milan.
Why book with Omio over Wanderu, Trainline or Checkmybus?
- Compare with other providers: On Omio, you can also compare tickets for the likes of Itabus or Curcio Viaggi to find the best option for your trip from Siena to Milan.
- Multiple modes of transport: Omio allows you to compare travel options including bus, train and flight to find the ideal travel option from Siena to Milan.
Journey information
Overview: Bus from Siena to Milan
Buses from Siena to Milan run on average 26 times per day, taking around 5h 53m. Cheap bus tickets for this journey start at €8 if you book in advance.
There are 17 buses per day. The earliest bus runs at 00:10, the last at 23:55. The fastest bus covers the 293 km distance in 4h 50m.
Distance 293 km |
Average bus duration 5h 53m |
Cheapest ticket price €8 |
Buses per day 26 |
Direct buses 17 |
Fastest bus 4h 50m |
First bus 00:10 |
Last bus 23:55 |
Bus providers: FlixBus, Itabus, BlaBlaCar, Curcio Viaggi from Siena to MilanYou can travel by bus between Siena to Milan with FlixBus, Itabus, BlaBlaCar, Curcio Viaggi for as low as €8. When you search for schedules and tickets, Omio will show you the best journey
FlixBus
Itabus
BlaBlaCar
Curcio Viaggi
FAQs: Bus from Siena to Milan
Find answers to the most common questions about traveling from Siena to Milan by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Milan, this guide helps you travel smarter and with confidence.

- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
- Itabus
- Assistance
- Dedicated seating areas
- Accessible restrooms.
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
- Itabus
- You can cancel your ticket up to 24 hours before departure for a partial refund. Changes allowed for a fee.
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
- Itabus
- One carry-on bag up to 10kg and one checked bag up to 20kg.
- FlixBus
- Additional luggage can be purchased for a fee.
- Itabus
- 5€ per additional bag.
- FlixBus
- Small pets in carriers allowed
- guide dogs travel for free.
- Itabus
- Small pets allowed in carriers
- larger pets must be leashed and muzzled.
popular bus stations
Popular bus stations from Siena to Milan
- 06:00-23:00
- Free Wi-Fi
- Cafeteria Lampugnano (in the station)
- Trattoria Milano (0.5 km)
- Pizza Express (0.7 km).
- Available outside the station.
- Elevators, ramps
- Available in the station.
- Metro: M1 Bus: 68, 78, 80
- 06:00-22:00
- Free Wi-Fi
- Cafeteria Italiana (in the station)
- Fast Food Express (in the station)
- Trattoria Milano (0.5 km).
- Available outside the station.
- Elevators, ramps
- Available in the station.
- Bus: 121, 132 Metro: M3
Most popular bus connections from Siena
More options for your journey from Siena to Milan
Here are some other resources that might have the information you need
