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Compare train, bus, and flight for Prague to Frankfurt am Main
Omio recommends booking the train as it is the most popular option from Prague to Frankfurt am Main among Omio's users. If you are prioritising price take the bus with prices starting from €25. For those with little time consider booking a flight which can get you there in 3h 26m. In case you are seeking to minimise your carbon footprint the train is your best bet as it emits only 0.1 - 0.4kg. The ticket price range depends on the travel mode: a bus costs an average of €25, and a flight costs an average of €114.
Distance: 409 km
Compare train with
Most popular Train | Bus | Flight |
|---|---|---|
€79 Average price | €38 Average price Cheapest | €206 Average price |
6h 22m Average total duration 5h 52m Onboard + 30m Additional time* | 6h 58m Average total duration 6h 28m Onboard + 30m Additional time* | 6h 26m Average total duration Fastest 3h 26m Onboard + 3h 0m Additional time* |
0.1 - 0.4kg CO2 emissions Lowest | 0.4 - 1.0kg CO2 emissions | 1.2 - 2.5kg CO2 emissions |
![]() Most popular train company | ![]() Most popular bus company | ![]() Most popular airline |
Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
Travel optionsfrom Prague to Frankfurt am Main
How to get from Prague to Frankfurt am Main by train, bus or flight.
Our recommendation
The best way to travel from Prague to Frankfurt am Main is by taking a bus because it’s the best combination of price and speed.
(Prague -> Amsterdam)11:00 PM6h25Praha, ÚAN Florenc5:25 AMFrankfurt, Stuttgarter Straße (Fermomnibusbahnhof)€261One-way0 transfers
Cheapest
(Prague -> Amsterdam)11:00 PM6h25Praha, ÚAN Florenc5:25 AMFrankfurt, Stuttgarter Straße (Fermomnibusbahnhof)€261One-way0 transfers
Fastest
DE441012:00 PM1h00Prague Vaclav Havel Airport1:00 PMFrankfurt am Main Airport€1361One-way0 transfers
Other options
EC 458 · S5 · ICE 6996:31 PM7h40Prague hlavní nádraží2:11 AMFrankfurt (Main) Hbf€331One-way2 transfers
EC 458 · S5 · ICE 6996:31 PM8h08Prague hlavní nádraží2:39 AMFrankfurt Airport long-distance station€381One-way2 transfers
RJ 386 · IC 2448 · ICE 6974:31 PM7h13Prague hlavní nádraží11:44 PMFrankfurt (Main) Hbf€401One-way2 transfers
FlixBus10:55 AM8h30Praha, Na Knížecí7:25 PMFrankfurt am Main, Flughafen Frankfurt (Terminal 1 - Busparkplatz P36)€301One-way0 transfers
FlixBus10:30 AM8h55Praha, ÚAN Florenc7:25 PMFrankfurt am Main, Flughafen Frankfurt (Terminal 1 - Busparkplatz P36)€301One-way0 transfers
FlixBus4:15 PM8h05Praha, ÚAN Florenc12:20 AMFrankfurt am Main, Flughafen Frankfurt (Terminal 1 - Busparkplatz P36)€311One-way0 transfers
LH13972:20 PM1h10Prague Vaclav Havel Airport3:30 PMFrankfurt am Main Airport€951One-way0 transfers
LH13939:10 AM1h10Prague Vaclav Havel Airport10:20 AMFrankfurt am Main Airport€951One-way0 transfers
LH139511:40 AM1h10Prague Vaclav Havel Airport12:50 PMFrankfurt am Main Airport€951One-way0 transfers
Find all the dates and times for this journey by train, bus, flight, and ferry .
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FAQs: Travel from Prague to Frankfurt am Main
Travel to Frankfurt am Main easily. Whether you want fast, cheap or something entirely different, our travel experts have collected everything you need to know so you can find the best option from Prague to Frankfurt am Main.

This is compared to other travel options from Prague to Frankfurt am Main:
A bus is €41 less than a train for this route with tickets for a train from Prague to Frankfurt am Main costing on average €79.
A bus is €167 less than a flight for this route with tickets for a flight from Prague to Frankfurt am Main costing on average €206.
Other travel options to Frankfurt am Main take longer:
Train takes on average 5h 52m.
Bus takes on average 6h 28m.
- Around 51 flights per day.
- Around 30 buses per day.
- Around 15 trains per day.
However, we recommend checking specific travel dates for your route between Prague and Frankfurt am Main as scheduled services by train, bus, and flight can vary by season or day of the week.
- Flights mostly depart from Prague Vaclav Havel Airport and arrive in Frankfurt am Main Airport.
- Trains mostly depart from Prague hlavní nádraží and arrive in Frankfurt (Main) Hbf.
- Buses mostly depart from Praha, ÚAN Florenc and arrive in Frankfurt, Stuttgarter Straße (Fermomnibusbahnhof).
- Travel with FlixBus, BlaBlaCar Bus, Infobus, BlaBlaCar to go to Frankfurt am Main by bus.
- Travel with Lufthansa, Air Dolomiti, Condor Flugdienst, Lot Polish Airlines, Austrian Airlines, KLM, Lufthansa Cityline, KLM Cityhopper, Helvetic Airways to go to Frankfurt am Main by flight.
- Travel with Deutsche Bahn, České dráhy, Leo Express, ÖBB | Euro City (EC) to go to Frankfurt am Main by train.
- 14 direct buses per day with FlixBus, BlaBlaCar Bus, Infobus, BlaBlaCar.
- 7 direct flights per day with Lufthansa, Air Dolomiti, Condor Flugdienst, Lufthansa Cityline.
- 0 direct trains per day with ÖBB | Euro City (EC).
Travelling from Prague to Frankfurt am Main: related information
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