The cheapest and fastest buses from Florence Santa Maria Novella to Milan Centrale
Cheapest price
€13
Average price
€28
Fastest journey
3 h
Average duration
3 h 8 m
Buses per day
49
Distance
250 km
The best way to find a cheap bus ticket from Florence Santa Maria Novella to Milan Centrale is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Florence Santa Maria Novella to Milan Centrale will cost around €28 if you buy it on the day, but the cheapest tickets can be found for only €13.
Of the 49 buses that leave Florence Santa Maria Novella for Milan Centrale on Sat, Mar 21, 49 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Sat, Mar 21 the direct buses cover the 250 km distance in an average of 3 h 8 m but if you time it right, some buses will get you there in just 3 h .
On Sat, Mar 21 the slowest buses will take 3 h 15 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.
94742
2126
3802
3804
FlixBus


FlixBus
FlixBusTravel Information
Compare train, bus, and flight for Florence Santa Maria Novella to Milan Centrale
Omio recommends booking the train as it is the most popular option from Florence Santa Maria Novella to Milan Centrale among Omio's users. If you are prioritising price take the bus with prices starting from €7. For those with little time consider booking a train which can get you there in 3h 38m. The ticket price range depends on the travel mode: a bus costs an average of €7, and a flight costs an average of €103.
Distance: 250 km
Compare bus with
| Bus | Most popular Train | Flight |
|---|---|---|
€15 Average price Cheapest | €39 Average price | €113 Average price |
4h 37m Average total duration 4h 7m Onboard + 30m Additional time* | 4h 8m Average total duration Fastest 3h 38m Onboard + 30m Additional time* | 10h 19m Average total duration 7h 19m Onboard + 3h 0m Additional time* |
Direct Options | Direct Options | Direct Options |
Live departures
Florence Santa Maria Novella to Milan Centrale bus times
The table below shows live departures for Florence Santa Maria Novella to Milan Centrale buses for today, Friday, March 20. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
FlixBus | 12:50 PM Scandicci, Villa Costanza (Florence) | 5h30 | 6:20 PM Milano, Autostazione Lampugnano | 0 transfersDirect | |
94742 | 1:15 PM Scandicci, Villa Costanza (Florence) | 4h25 | 5:40 PM Milano, Autostazione Lampugnano | 0 transfersDirect | |
FlixBus | 1:20 PM Scandicci, Villa Costanza (Florence) | 4h10 | 5:30 PM Milano, San Donato - Settore B (Viale Giuseppe Impastato) | 0 transfersDirect | |
FlixBus | 1:20 PM Scandicci, Villa Costanza (Florence) | 4h55 | 6:15 PM Milano, Autostazione Lampugnano | 0 transfersDirect | |
FlixBus | 3:10 PM Scandicci, Villa Costanza (Florence) | 5h00 | 8:10 PM Assago, Viale Milanofiori (Assago M2) | 0 transfersDirect | |
FlixBus | 3:10 PM Scandicci, Villa Costanza (Florence) | 5h30 | 8:40 PM Milano, Autostazione Lampugnano | 0 transfersDirect | |
3804 | 3:20 PM Scandicci, Villa Costanza (Florence) | 5h05 | 8:25 PM Milano, Autostazione Lampugnano | 0 transfersDirect | |
FlixBus | 4:05 PM Scandicci, Villa Costanza (Florence) | 3h50 | 7:55 PM Milano, San Donato - Settore B (Viale Giuseppe Impastato) | 0 transfersDirect | |
FlixBus | 5:30 PM Scandicci, Villa Costanza (Florence) | 3h25 | 8:55 PM Milano, San Donato - Settore B (Viale Giuseppe Impastato) | 0 transfersDirect | |
FlixBus | 5:30 PM Scandicci, Villa Costanza (Florence) | 4h10 | 9:40 PM Milano, Autostazione Lampugnano | 0 transfersDirect | |
FlixBus | 5:45 PM Scandicci, Villa Costanza (Florence) | 4h50 | 10:35 PM Milano, Autostazione Lampugnano | 0 transfersDirect | |
FlixBus | 6:45 PM Scandicci, Villa Costanza (Florence) | 3h50 | 10:35 PM Milano, Autostazione Lampugnano | 0 transfersDirect | |
FlixBus | 6:45 PM Scandicci, Villa Costanza (Florence) | 3h15 | 10:00 PM Milano, San Donato - Settore B (Viale Giuseppe Impastato) | 0 transfersDirect | |
FlixBus | 7:00 PM Scandicci, Villa Costanza (Florence) | 5h05 | 12:05 AM Milano, Autostazione Lampugnano | 0 transfersDirect | |
FlixBus | 10:40 PM Firenze, Piazzale Montelungo | 4h20 | 3:00 AM Milano, Autostazione Lampugnano | 0 transfersDirect | |
FlixBus | 11:05 PM Scandicci, Villa Costanza (Florence) | 3h55 | 3:00 AM Milano, Autostazione Lampugnano | 0 transfersDirect | |
| Saturday, March 21 | |||||
3898 | 12:05 AM Scandicci, Villa Costanza (Florence) | 5h05 | 5:10 AM Milano, Autostazione Lampugnano | 0 transfersDirect | |
2494 | 1:05 AM Scandicci, Villa Costanza (Florence) | 4h50 | 5:55 AM Milano, Autostazione Lampugnano | 0 transfersDirect | |
054 | 1:15 AM Scandicci, Villa Costanza (Florence) | 4h45 | 6:00 AM Milano, Autostazione Lampugnano | 0 transfersDirect | |
054 | 1:15 AM Scandicci, Villa Costanza (Florence) | 4h10 | 5:25 AM Milano, San Donato - Settore B (Viale Giuseppe Impastato) | 0 transfersDirect | |
FlixBus | 1:15 AM Firenze, Piazzale Montelungo | 4h40 | 5:55 AM Milano, Autostazione Lampugnano | 0 transfersDirect | |
FlixBus | 1:40 AM Scandicci, Villa Costanza (Florence) | 4h15 | 5:55 AM Milano, Autostazione Lampugnano | 0 transfersDirect | |
FlixBus | 3:10 AM Firenze, Piazzale Montelungo | 4h30 | 7:40 AM Milano, Autostazione Lampugnano | 0 transfersDirect | |
FlixBus | 3:10 AM Firenze, Piazzale Montelungo | 3h40 | 6:50 AM Milano, San Donato - Settore B (Viale Giuseppe Impastato) | 0 transfersDirect | |
FlixBus | 3:35 AM Scandicci, Villa Costanza (Florence) | 4h05 | 7:40 AM Milano, Autostazione Lampugnano | 0 transfersDirect | |
FlixBus | 3:35 AM Scandicci, Villa Costanza (Florence) | 3h15 | 6:50 AM Milano, San Donato - Settore B (Viale Giuseppe Impastato) | 0 transfersDirect | |
FlixBus | 5:35 AM Scandicci, Villa Costanza (Florence) | 4h35 | 10:10 AM Milano, Autostazione Lampugnano | 0 transfersDirect | |
FlixBus | 5:35 AM Scandicci, Villa Costanza (Florence) | 3h50 | 9:25 AM Milano, San Donato - Settore B (Viale Giuseppe Impastato) | 0 transfersDirect | |
FlixBus | 6:15 AM Scandicci, Villa Costanza (Florence) | 4h40 | 10:55 AM Milano, Autostazione Lampugnano | 0 transfersDirect | |
FlixBus | 6:40 AM Scandicci, Villa Costanza (Florence) | 4h15 | 10:55 AM Sesto San Giovanni, Piazza Primo Maggio (Stazione ferroviaria) | 0 transfersDirect | |
FlixBus | 6:40 AM Scandicci, Villa Costanza (Florence) | 3h50 | 10:30 AM Milano, San Donato - Settore B (Viale Giuseppe Impastato) | 0 transfersDirect | |
FlixBus | 7:55 AM Scandicci, Villa Costanza (Florence) | 4h50 | 12:45 PM Milano, Autostazione Lampugnano | 0 transfersDirect | |
FlixBus | 8:20 AM Scandicci, Villa Costanza (Florence) | 4h05 | 12:25 PM Milano, Autostazione Lampugnano | 0 transfersDirect | |
FlixBus | 8:20 AM Scandicci, Villa Costanza (Florence) | 3h25 | 11:45 AM Milano, San Donato - Settore B (Viale Giuseppe Impastato) | 0 transfersDirect | |
3492 | 9:20 AM Scandicci, Villa Costanza (Florence) | 4h25 | 1:45 PM Milano, Autostazione Lampugnano | 0 transfersDirect | |
FlixBus | 9:20 AM Scandicci, Villa Costanza (Florence) | 5h00 | 2:20 PM Milano, Autostazione Lampugnano | 0 transfersDirect | |
FlixBus | 9:20 AM Scandicci, Villa Costanza (Florence) | 4h15 | 1:35 PM Milano, San Donato - Settore B (Viale Giuseppe Impastato) | 0 transfersDirect | |
FlixBus | 10:25 AM Scandicci, Villa Costanza (Florence) | 5h00 | 3:25 PM Milano, Autostazione Lampugnano | 0 transfersDirect | |
2126 | 10:55 AM Scandicci, Villa Costanza (Florence) | 4h45 | 3:40 PM Milano, Autostazione Lampugnano | 0 transfersDirect | |
FlixBus | 10:55 AM Scandicci, Villa Costanza (Florence) | 4h35 | 3:30 PM Assago, Viale Milanofiori (Assago M2) | 0 transfersDirect | |
FlixBus | 10:55 AM Scandicci, Villa Costanza (Florence) | 5h15 | 4:10 PM Milano, Autostazione Lampugnano | 0 transfersDirect | |
3802 | 11:20 AM Scandicci, Villa Costanza (Florence) | 4h50 | 4:10 PM Milano, Autostazione Lampugnano | 0 transfersDirect | |
3802 | 11:35 AM Prato, Piazzale Del Museo | 4h35 | 4:10 PM Milano, Autostazione Lampugnano | 0 transfersDirect | |
FlixBus | 12:35 PM Scandicci, Villa Costanza (Florence) | 5h00 | 5:35 PM Milano, Autostazione Lampugnano | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Florence Santa Maria Novella to Milan Centrale by train, bus, or flight
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Why should you book Florence Santa Maria Novella to Milan Centrale buses with Omio?
Why book with Omio vs Itabus?
- Compare with other providers: On Omio, you can not only buy tickets for Itabus, but also compare tickets for the likes of FlixBus, BlaBlaCar Bus, Infobus or Calanda Viaggi to find the best option for your trip from Florence Santa Maria Novella to Milan Centrale.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Itabus with all available travel options, which are train, bus and flight to ensure you get the best deal for traveling from Florence Santa Maria Novella to Milan Centrale.
Why book with Omio over Checkmybus, Wanderu or Trainline?
- Compare with other providers: On Omio, you can also compare tickets for the likes of FlixBus, BlaBlaCar Bus, Infobus or Calanda Viaggi to find the best option for your trip from Florence Santa Maria Novella to Milan Centrale.
- Multiple modes of transport: Omio allows you to compare travel options including train, bus and flight to find the ideal travel option from Florence Santa Maria Novella to Milan Centrale.
Journey information
Overview: Bus from Florence Santa Maria Novella to Milan Centrale
Buses from Florence Santa Maria Novella to Milan Centrale run on average 29 times per day, taking around 4h 7m. Cheap bus tickets for this journey start at €7 if you book in advance.
There are 24 buses per day. The earliest bus runs at 00:05, the last at 22:40. The fastest bus covers the 250 km distance in 3h 15m.
Distance 250 km |
Average bus duration 4h 7m |
Cheapest ticket price €7 |
Buses per day 29 |
Direct buses 24 |
Fastest bus 3h 15m |
First bus 00:05 |
Last bus 22:40 |
Bus providers: Itabus, FlixBus, BlaBlaCar, BlaBlaCar Bus, Infobus, Calanda Viaggi, Marino Autolinee from Florence Santa Maria Novella to Milan CentraleYou can travel by bus between Florence Santa Maria Novella to Milan Centrale with Itabus, FlixBus, BlaBlaCar, BlaBlaCar Bus, Infobus, Calanda Viaggi, Marino Autolinee for as low as €7. When you search for schedules and tickets, Omio will show you the best journey
Itabus
FlixBus
Infobus
Marino Autolinee
BlaBlaCar Bus
Calanda Viaggi
BlaBlaCar
FAQs: Bus from Florence Santa Maria Novella to Milan Centrale
Find answers to the most common questions about traveling from Florence Santa Maria Novella to Milan Centrale by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Milan Centrale, this guide helps you travel smarter and with confidence.

- BlaBlaCar Bus
- Assistance
- Priority boarding
- Accessible seating options.
- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
- Itabus
- Assistance
- Dedicated seating areas
- Accessible restrooms.
- BlaBlaCar Bus
- You can cancel your ticket up to 30 minutes before departure for a refund in the form of a voucher.
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
- Itabus
- You can cancel your ticket up to 24 hours before departure for a partial refund. Changes allowed for a fee.
- BlaBlaCar Bus
- One carry-on bag up to 7kg and one checked bag up to 20kg.
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
- Itabus
- One carry-on bag up to 10kg and one checked bag up to 20kg.
- BlaBlaCar Bus
- Additional luggage can be purchased for a fee.
- FlixBus
- Additional luggage can be purchased for a fee.
- Itabus
- 5€ per additional bag.
- Infobus
- Small pets allowed in carriers
- larger pets may require a separate ticket.
- FlixBus
- Small pets in carriers allowed
- guide dogs travel for free.
- Itabus
- Small pets allowed in carriers
- larger pets must be leashed and muzzled.
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