The cheapest and fastest buses from Florence Santa Maria Novella to Milan Centrale
Cheapest price on Sep 18
€56
Average ticket price on Sep 18
€56
Fastest journey on Sep 18
3 h 38 m
Average journey duration on Sep 18
4 h 12 m
Buses on Sep 18
12
Distance
250 km
The best way to find a cheap bus ticket from Florence Santa Maria Novella to Milan Centrale is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Florence Santa Maria Novella to Milan Centrale will cost around €56 if you buy it on the day, but the cheapest tickets can be found for only €56.
It's difficult to get from Florence Santa Maria Novella to Milan Centrale without transferring at least 2 times.
Regionale 18492 · Autobus TTPER B0404+
998612:37 PM5h38Florence Santa Maria Novella6:15 PMMilan Centrale€561One-way2 transfers
Regionale 18664 · Autobus TTPER B0400+
998210:20 AM5h55Florence Santa Maria Novella4:15 PMMilan Centrale€561One-way2 transfers
Regionale 18664 · Autobus TTPER B0400+
997810:20 AM3h55Florence Santa Maria Novella2:15 PMMilan Centrale€561One-way2 transfers
Regionale 18508 · Treno 17820 effettuato con bus FI680+
99789:09 AM5h06Florence Santa Maria Novella2:15 PMMilan Centrale€561One-way2 transfers
Regionale 18490 · Autobus TTPER B0402+
993211:38 AM4h42Florence Santa Maria Novella4:20 PMMilan Centrale€561One-way2 transfers
Regionale 18492 · Autobus TTPER B0404+
998212:37 PM3h38Florence Santa Maria Novella4:15 PMMilan Centrale€561One-way2 transfers
Regionale 18664 · Autobus TTPER B0400+
997810:20 AM3h55Florence Santa Maria Novella2:15 PMMilan Centrale€561One-way2 transfers
Regionale 18508 · Treno 17820 effettuato con bus FI680+
99769:09 AM4h06Florence Santa Maria Novella1:15 PMMilan Centrale€561One-way2 transfers
Regionale 18490 · Autobus TTPER B0402+
998211:38 AM4h37Florence Santa Maria Novella4:15 PMMilan Centrale€561One-way2 transfers
Regionale 18490 · Autobus TTPER B0402+
993211:38 AM4h42Florence Santa Maria Novella4:20 PMMilan Centrale€561One-way2 transfers
Travel Information
Compare train, bus, and flight for Florence Santa Maria Novella to Milan Centrale
Omio recommends booking the flight as it is the most popular option from Florence Santa Maria Novella to Milan Centrale among Omio's users. If you are prioritising price, take the bus, with an average ticket price of €20 For those with little time, consider booking a train, which has an average total journey time of 3h 12m. Average ticket prices depend on the travel mode: a bus costs an average of €20, while a flight costs an average of €322.
Distance: 250 km
Compare bus with
| Bus | Most popular Flight | Train | Driving |
|---|---|---|---|
€20 Average price Cheapest | €322 Average price | €32 Average price | €74 Average price (fuel + tolls) |
5h 8m Average total duration 4h 38m Onboard + 30m Additional time* | 5h 6m Average total duration 3h 6m Onboard + 2h 0m Additional time* | 3h 12m Average total duration Fastest 2h 42m Onboard + 30m Additional time* | 3h 20m Average total duration (door-to-door) |
Direct Options | Direct Options | Direct Options | Direct Options |
This is compared to other travel options from Florence Santa Maria Novella to Milan Centrale:
A bus is €14 less than a train for this route with tickets for a train from Florence Santa Maria Novella to Milan Centrale costing on average €28.
A bus is €226 less than a flight for this route with tickets for a flight from Florence Santa Maria Novella to Milan Centrale costing on average €240.
Other travel options to Milan Centrale take longer:
Bus takes on average 4h 10m.
Flight takes on average 4h 14m.
Live departures
Florence Santa Maria Novella to Milan Centrale bus times
The table below shows live departures for Florence Santa Maria Novella to Milan Centrale buses for today, Thursday, September 17. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
Regionale 18508 · Treno 17820 effettuato con bus FI680+ 9976 | 9:09 AM Florence Santa Maria Novella | 4h06 | 1:15 PM Milan Centrale | 2 transfers | |
Regionale 18508 · Treno 17820 effettuato con bus FI680+ 9924 | 9:09 AM Florence Santa Maria Novella | 5h11 | 2:20 PM Milan Centrale | 2 transfers | |
Regionale 18508 · Treno 17820 effettuato con bus FI680+ 9978 | 9:09 AM Florence Santa Maria Novella | 5h06 | 2:15 PM Milan Centrale | 2 transfers | |
Regionale 18664 · Autobus TTPER B0400+ 9928 | 10:20 AM Florence Santa Maria Novella | 5h00 | 3:20 PM Milan Centrale | 2 transfers | |
Regionale 18664 · Autobus TTPER B0400+ 9982 | 10:20 AM Florence Santa Maria Novella | 5h55 | 4:15 PM Milan Centrale | 2 transfers | |
Regionale 18664 · Autobus TTPER B0400+ 9978 | 10:20 AM Florence Santa Maria Novella | 3h55 | 2:15 PM Milan Centrale | 2 transfers | |
Regionale 18490 · Autobus TTPER B0402+ 9982 | 11:38 AM Florence Santa Maria Novella | 4h37 | 4:15 PM Milan Centrale | 2 transfers | |
Regionale 18490 · Autobus TTPER B0402+ 9932 | 11:38 AM Florence Santa Maria Novella | 4h42 | 4:20 PM Milan Centrale | 2 transfers | |
Regionale 18490 · Autobus TTPER B0402+ 8134 | 11:38 AM Florence Santa Maria Novella | 5h42 | 5:20 PM Milan Centrale | 2 transfers | |
Regionale 18492 · Autobus TTPER B0404+ 9986 | 12:37 PM Florence Santa Maria Novella | 5h38 | 6:15 PM Milan Centrale | 2 transfers | |
Regionale 18492 · Autobus TTPER B0404+ 9982 | 12:37 PM Florence Santa Maria Novella | 3h38 | 4:15 PM Milan Centrale | 2 transfers | |
Regionale 18492 · Autobus TTPER B0404+ 8134 | 12:37 PM Florence Santa Maria Novella | 4h43 | 5:20 PM Milan Centrale | 2 transfers | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Florence Santa Maria Novella to Milan Centrale by train, bus, or flight
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Why should you book Florence Santa Maria Novella to Milan Centrale buses with Omio?
Why book with Omio vs FlixBus?
- Compare with other providers: On Omio, you can not only buy tickets for FlixBus, but also compare tickets for the likes of Itabus, BlaBlaCar Bus, Marino Autolinee or Calanda Viaggi to find the best option for your trip from Florence Santa Maria Novella to Milan Centrale.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare FlixBus with all available travel options, which are train, bus and flight to ensure you get the best deal for traveling from Florence Santa Maria Novella to Milan Centrale.
Why book with Omio over Wanderu, Trainline or Checkmybus?
- Compare with other providers: On Omio, you can also compare tickets for the likes of Itabus, BlaBlaCar Bus, Marino Autolinee or Calanda Viaggi to find the best option for your trip from Florence Santa Maria Novella to Milan Centrale.
- Multiple modes of transport: Omio allows you to compare travel options including train, bus and flight to find the ideal travel option from Florence Santa Maria Novella to Milan Centrale.
Journey information
Overview: Bus from Florence Santa Maria Novella to Milan Centrale
Buses from Florence Santa Maria Novella to Milan Centrale run on average 31 times per day, taking around 4h 10m. Cheap bus tickets for this journey start at €8 if you book in advance.
There are 26 buses per day. The earliest bus runs at 00:15, the last at 23:50. The fastest bus covers the 250 km distance in 3h 15m.
Distance 250 km |
Average bus duration 4h 10m |
Cheapest ticket price €8 |
Buses per day 31 |
Direct buses 26 |
Fastest bus 3h 15m |
First bus 12:15 AM |
Last bus 11:50 PM |
Cheapest Month Jun |
Cheapest Day Sat |
High Season Oct - Dec |
Low Season Jan - Mar |
Busiest Day Thu |
Least Busy Day Sat |
Best time to book 7 days |
Bus providers: FlixBus, Itabus, BlaBlaCar, BlaBlaCar Bus, Marino Autolinee, Calanda Viaggi from Florence Santa Maria Novella to Milan CentraleYou can travel by bus between Florence Santa Maria Novella to Milan Centrale with FlixBus, Itabus, BlaBlaCar, BlaBlaCar Bus, Marino Autolinee, Calanda Viaggi for as low as €8. When you search for schedules and tickets, Omio will show you the best journey
FlixBus
Itabus
Marino Autolinee
BlaBlaCar Bus
Calanda Viaggi
BlaBlaCar
FAQs: Bus from Florence Santa Maria Novella to Milan Centrale
Find answers to the most common questions about traveling from Florence Santa Maria Novella to Milan Centrale by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Milan Centrale, this guide helps you travel smarter and with confidence.

- BlaBlaCar Bus
- Assistance
- Priority boarding
- Accessible seating options.
- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
- Itabus
- Assistance
- Dedicated seating areas
- Accessible restrooms.
- BlaBlaCar Bus
- You can cancel your ticket up to 30 minutes before departure for a refund in the form of a voucher.
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
- Itabus
- You can cancel your ticket up to 24 hours before departure for a partial refund. Changes allowed for a fee.
- BlaBlaCar Bus
- One carry-on bag up to 7kg and one checked bag up to 20kg.
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
- Itabus
- One carry-on bag up to 10kg and one checked bag up to 20kg.
- BlaBlaCar Bus
- Additional luggage can be purchased for a fee.
- FlixBus
- Additional luggage can be purchased for a fee.
- Itabus
- 5€ per additional bag.
- Marino Autolinee
- Small pets allowed in carriers
- larger pets must be leashed and muzzled.
- FlixBus
- Small pets in carriers allowed
- guide dogs travel for free.
- Itabus
- Small pets allowed in carriers
- larger pets must be leashed and muzzled.
More options for your journey from Florence Santa Maria Novella to Milan Centrale
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