The cheapest and fastest buses from Florence Santa Maria Novella to Milan Centrale
Cheapest price
€26
Average price
€26
Fastest journey
8 h 8 m
Average duration
8 h 41 m
Buses per day
2
Distance
250 km
The best way to find a cheap bus ticket from Florence Santa Maria Novella to Milan Centrale is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Florence Santa Maria Novella to Milan Centrale will cost around €26 if you buy it on the day, but the cheapest tickets can be found for only €26.
It's difficult to get from Florence Santa Maria Novella to Milan Centrale without transferring at least 2 times.
Regionale 18502 · Regionale 17808+
BUS L580A7:09 AM8h08Florence Santa Maria Novella3:17 PMMilan Centrale€261One-way2 transfers
Regionale 18488 · Regionale 17806+
BUS L580A6:03 AM9h14Florence Santa Maria Novella3:17 PMMilan Centrale€261One-way2 transfers
Regionale 18502 · Regionale 17808+
BUS L580A7:09 AM8h08Florence Santa Maria Novella3:17 PMMilan Centrale€261One-way2 transfers
Regionale 18488 · Regionale 17806+
BUS L580A6:03 AM9h14Florence Santa Maria Novella3:17 PMMilan Centrale€261One-way2 transfers
Travel Information
Compare bus, train, and flight for Florence Santa Maria Novella to Milan Centrale
Omio recommends booking the train as it is the most popular option from Florence Santa Maria Novella to Milan Centrale among Omio's users. If you are prioritising price take the bus with prices starting from €8. For those with little time consider booking a train which can get you there in 3h 40m. The ticket price range depends on the travel mode: a bus costs an average of €8, and a flight costs an average of €104.
Distance: 250 km
Compare bus with
| Bus | Most popular Train | Flight |
|---|---|---|
€18 Average price Cheapest | €35 Average price | €104 Average price |
4h 39m Average total duration 4h 9m Onboard + 30m Additional time* | 4h 10m Average total duration Fastest 3h 40m Onboard + 30m Additional time* | 9h 38m Average total duration 6h 38m Onboard + 3h 0m Additional time* |
Direct Options | Direct Options | Direct Options |
Live departures
Florence Santa Maria Novella to Milan Centrale bus times
The table below shows live departures for Florence Santa Maria Novella to Milan Centrale buses for today, Thursday, June 18. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 9:00 PM Florence Santa Maria Novella | 6h00 | 3:00 AM Milan Centrale | 0 transfersDirect | |
![]() | 9:40 PM Florence Santa Maria Novella | 6h10 | 3:50 AM Milan Centrale | 0 transfersDirect | |
![]() | 10:40 PM Florence Santa Maria Novella | 6h10 | 4:50 AM Milan Centrale | 0 transfersDirect | |
| Friday, June 19 | |||||
Regionale 18488 · Regionale 17806+ BUS L580A | 6:03 AM Florence Santa Maria Novella | 9h14 | 3:17 PM Milan Centrale | 2 transfers | |
Regionale 18502 · Regionale 17808+ BUS L580A | 7:09 AM Florence Santa Maria Novella | 8h08 | 3:17 PM Milan Centrale | 2 transfers | |
Find all the dates and times for this journey
Compare prices and tickets Florence Santa Maria Novella to Milan Centrale by bus, train, or flight
Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Why should you book Florence Santa Maria Novella to Milan Centrale buses with Omio?
Why book with Omio vs FlixBus?
- Compare with other providers: On Omio, you can not only buy tickets for FlixBus, but also compare tickets for the likes of Itabus, BlaBlaCar Bus, Marino Autolinee or Calanda Viaggi to find the best option for your trip from Florence Santa Maria Novella to Milan Centrale.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare FlixBus with all available travel options, which are bus, train and flight to ensure you get the best deal for traveling from Florence Santa Maria Novella to Milan Centrale.
Why book with Omio over Wanderu, Trainline or Checkmybus?
- Compare with other providers: On Omio, you can also compare tickets for the likes of Itabus, BlaBlaCar Bus, Marino Autolinee or Calanda Viaggi to find the best option for your trip from Florence Santa Maria Novella to Milan Centrale.
- Multiple modes of transport: Omio allows you to compare travel options including bus, train and flight to find the ideal travel option from Florence Santa Maria Novella to Milan Centrale.
Journey information
Overview: Bus from Florence Santa Maria Novella to Milan Centrale
Buses from Florence Santa Maria Novella to Milan Centrale run on average 32 times per day, taking around 4h 9m. Cheap bus tickets for this journey start at €8 if you book in advance.
There are 27 buses per day. The earliest bus runs at 00:05, the last at 23:20. The fastest bus covers the 250 km distance in 3h 15m.
Distance 250 km |
Average bus duration 4h 9m |
Cheapest ticket price €8 |
Buses per day 32 |
Direct buses 27 |
Fastest bus 3h 15m |
First bus 12:05 AM |
Last bus 11:20 PM |
Cheapest Month Aug |
Cheapest Day Sat |
High Season Apr - Jun |
Low Season Jan - Mar |
Busiest Day Mon |
Least Busy Day Sat |
Bus providers: FlixBus, Itabus, BlaBlaCar, BlaBlaCar Bus, Marino Autolinee, Calanda Viaggi from Florence Santa Maria Novella to Milan CentraleYou can travel by bus between Florence Santa Maria Novella to Milan Centrale with FlixBus, Itabus, BlaBlaCar, BlaBlaCar Bus, Marino Autolinee, Calanda Viaggi for as low as €8. When you search for schedules and tickets, Omio will show you the best journey
FlixBus
Itabus
Marino Autolinee
BlaBlaCar Bus
Calanda Viaggi
BlaBlaCar
FAQs: Bus from Florence Santa Maria Novella to Milan Centrale
Find answers to the most common questions about traveling from Florence Santa Maria Novella to Milan Centrale by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Milan Centrale, this guide helps you travel smarter and with confidence.

- BlaBlaCar Bus
- Assistance
- Priority boarding
- Accessible seating options.
- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
- Itabus
- Assistance
- Dedicated seating areas
- Accessible restrooms.
- BlaBlaCar Bus
- You can cancel your ticket up to 30 minutes before departure for a refund in the form of a voucher.
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
- Itabus
- You can cancel your ticket up to 24 hours before departure for a partial refund. Changes allowed for a fee.
- BlaBlaCar Bus
- One carry-on bag up to 7kg and one checked bag up to 20kg.
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
- Itabus
- One carry-on bag up to 10kg and one checked bag up to 20kg.
- BlaBlaCar Bus
- Additional luggage can be purchased for a fee.
- FlixBus
- Additional luggage can be purchased for a fee.
- Itabus
- 5€ per additional bag.
- Marino Autolinee
- Small pets allowed in carriers
- larger pets must be leashed and muzzled.
- FlixBus
- Small pets in carriers allowed
- guide dogs travel for free.
- Itabus
- Small pets allowed in carriers
- larger pets must be leashed and muzzled.
More options for your journey from Florence Santa Maria Novella to Milan Centrale
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