The cheapest and fastest buses from Karlsruhe to Prague
Cheapest price
€44
Average price
€72
Fastest journey
8 h 5 m
Average duration
8 h 28 m
Buses per day
26
Distance
452 km
The best way to find a cheap bus ticket from Karlsruhe to Prague is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Karlsruhe to Prague will cost around €72 if you buy it on the day, but the cheapest tickets can be found for only €44.
Of the 26 buses that leave Karlsruhe for Prague on Thu, May 14, 8 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Thu, May 14 the direct buses cover the 452 km distance in an average of 8 h 28 m but if you time it right, some buses will get you there in just 8 h 5 m .
On Thu, May 14 the slowest buses will take 8 h 47 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.
FlixBus1:20 PM8h30Karlsruhe Hbf9:50 PMPraha, ÚAN Florenc€441One-way0 transfers
FlixBus11:25 PM8h25Karlsruhe Hbf7:50 AMPraha, ÚAN Florenc€521One-way0 transfers
FlixBus12:15 PM10h25Karlsruhe Hbf10:40 PMPraha, ÚAN Florenc€521One-way0 transfers
FlixBus11:25 PM8h05Karlsruhe Hbf7:30 AMPraha, M. Horákové (Hradčanská)€521One-way0 transfers
FlixBus · FlixBus1:20 PM11h05Karlsruhe Hbf12:25 AMPrague, Central Train Station€611One-way1 transfer
FlixBus11:25 PM8h05Karlsruhe Hbf7:30 AMPraha, M. Horákové (Hradčanská)€521One-way0 transfers
FlixBus11:25 PM8h25Karlsruhe Hbf7:50 AMPraha, ÚAN Florenc€521One-way0 transfers
FlixBus1:20 PM8h30Karlsruhe Hbf9:50 PMPraha, ÚAN Florenc€441One-way0 transfers
FlixTrain+
FlixBus2:23 PM8h32Karlsruhe Hbf10:55 PMPraha, Na Knížecí€731One-way1 transfer
FlixTrain+
FlixBus2:23 PM8h47Karlsruhe Hbf11:10 PMPraha, ÚAN Florenc€731One-way1 transfer
Travel Information
Compare train and bus for Karlsruhe to Prague
Omio recommends booking the train as it is the most popular option from Karlsruhe to Prague among Omio's users. If you are prioritising price take the bus with prices starting from €25. For those with little time consider booking a bus which can get you there in 7h 29m. In case you are seeking to minimise your carbon footprint the train is your best bet as it emits only 0.1 - 0.4kg. The ticket price range depends on the travel mode: a bus costs an average of €25, and a train costs an average of €28.
Distance: 452 km
Compare bus with
| Bus | Most popular Train |
|---|---|
€40 Average price Cheapest | €64 Average price |
7h 59m Average total duration Fastest 7h 29m Onboard + 30m Additional time* | 9h 35m Average total duration 9h 5m Onboard + 30m Additional time* |
0.5 - 1.1kg CO2 emissions | 0.1 - 0.4kg CO2 emissions Lowest |
![]() Most popular bus company | ![]() Most popular train company |
Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
Live departures
Karlsruhe to Prague bus times
The table below shows live departures for Karlsruhe to Prague buses for today, Wednesday, May 13. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
FlixBus · FlixBus | 11:20 PM Karlsruhe Hbf | 11h15 | 10:35 AM Prague, Central Train Station | 1 transfer | |
FlixBus · FlixBus | 11:25 PM Karlsruhe Hbf | 9h30 | 8:55 AM Praha, Na Knížecí | 1 transfer | |
FlixBus · FlixBus | 11:25 PM Karlsruhe Hbf | 9h55 | 9:20 AM Praha, ÚAN Florenc | 1 transfer | |
| Thursday, May 14 | |||||
FlixBus · FlixBus | 12:05 AM Karlsruhe Hbf | 10h40 | 10:45 AM Praha, ÚAN Florenc | 1 transfer | |
FlixBus · FlixBus | 12:05 AM Karlsruhe Hbf | 10h30 | 10:35 AM Prague, Central Train Station | 1 transfer | |
FlixBus · FlixBus | 2:15 AM Karlsruhe Hbf | 11h15 | 1:30 PM Praha, ÚAN Florenc | 1 transfer | |
FlixBus · FlixBus | 2:15 AM Karlsruhe Hbf | 11h05 | 1:20 PM Prague, Central Train Station | 1 transfer | |
FlixBus · FlixBus | 2:15 AM Karlsruhe Hbf | 9h55 | 12:10 PM Prague, Central Train Station | 1 transfer | |
FlixBus · FlixBus | 2:15 AM Karlsruhe Hbf | 10h10 | 12:25 PM Praha, ÚAN Florenc | 1 transfer | |
FlixBus | 6:25 AM Karlsruhe Hbf | 9h00 | 3:25 PM Praha, ÚAN Florenc | 0 transfersDirect | |
FlixBus | 6:25 AM Karlsruhe Hbf | 9h45 | 4:10 PM Praha, Černý Most | 0 transfersDirect | |
FlixBus | 8:35 AM Karlsruhe Hbf | 8h55 | 5:30 PM Prague, Central Train Station | 0 transfersDirect | |
FlixBus | 8:35 AM Karlsruhe Hbf | 9h10 | 5:45 PM Praha, ÚAN Florenc | 0 transfersDirect | |
FlixBus · FlixBus | 10:15 AM Karlsruhe Hbf | 10h05 | 8:20 PM Praha, Na Knížecí | 1 transfer | |
FlixBus · FlixBus | 12:15 PM Karlsruhe Hbf | 8h55 | 9:10 PM Praha, Na Knížecí | 1 transfer | |
FlixBus | 12:15 PM Karlsruhe Hbf | 10h25 | 10:40 PM Praha, ÚAN Florenc | 0 transfersDirect | |
FlixBus · FlixBus | 12:15 PM Karlsruhe Hbf | 11h40 | 11:55 PM Prague, Central Train Station | 1 transfer | |
FlixBus · FlixBus | 1:20 PM Karlsruhe Hbf | 11h05 | 12:25 AM Prague, Central Train Station | 1 transfer | |
FlixBus · FlixBus | 1:20 PM Karlsruhe Hbf | 9h35 | 10:55 PM Praha, Na Knížecí | 1 transfer | |
FlixBus | 1:20 PM Karlsruhe Hbf | 8h30 | 9:50 PM Praha, ÚAN Florenc | 0 transfersDirect | |
FlixTrain+ FlixBus | 2:23 PM Karlsruhe Hbf | 8h47 | 11:10 PM Praha, ÚAN Florenc | 1 transfer | |
FlixTrain+ FlixBus | 2:23 PM Karlsruhe Hbf | 8h32 | 10:55 PM Praha, Na Knížecí | 1 transfer | |
FlixBus · FlixBus | 4:20 PM Karlsruhe Hbf | 10h55 | 3:15 AM Prague, Central Train Station | 1 transfer | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Karlsruhe to Prague by train or bus
Compare train and bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
May 14
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May 18
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May 20
May 21
May 22
May 23
May 24
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May 27
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Jun 01
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Jun 03
Why should you book Karlsruhe to Prague buses with Omio?
Why book with Omio vs FlixBus?
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare FlixBus with all available travel options, which are train and bus to ensure you get the best deal for traveling from Karlsruhe to Prague.
Why book with Omio over Wanderu or Trainline?
- Multiple modes of transport: Omio allows you to compare travel options including train and bus to find the ideal travel option from Karlsruhe to Prague.
Journey information
Overview: Bus from Karlsruhe to Prague
Buses from Karlsruhe to Prague run on average 24 times per day, taking around 7h 29m. Cheap bus tickets for this journey start at €25 if you book in advance.
There are 8 buses per day. The earliest bus runs at 00:05, the last at 23:50. The fastest bus covers the 452 km distance in 8h 5m.
Distance 452 km |
Average bus duration 7h 29m |
Cheapest ticket price €25 |
Buses per day 24 |
Direct buses 8 |
Fastest bus 8h 5m |
First bus 12:05 AM |
Last bus 11:50 PM |
Cheapest Month Mar |
Cheapest Day Mon |
High Season Oct - Dec |
Low Season Jan - Mar |
Busiest Day Fri |
Least Busy Day Wed |
Best time to book 63 days |
Bus providers: FlixBus, BlaBlaCar from Karlsruhe to PragueYou can travel by bus between Karlsruhe to Prague with FlixBus, BlaBlaCar for as low as €25. When you search for schedules and tickets, Omio will show you the best journey
FlixBus
BlaBlaCar
FAQs: Bus from Karlsruhe to Prague
Find answers to the most common questions about traveling from Karlsruhe to Prague by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Prague, this guide helps you travel smarter and with confidence.

- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
- FlixBus
- Additional luggage can be purchased for a fee.
- FlixBus
- Small pets in carriers allowed
- guide dogs travel for free.
popular bus stations
Popular bus stations from Karlsruhe to Prague
- 00:00-23:59
- Free Wi-Fi
- Czech Bistro (in the station)
- Fast Food Express (in the station)
- Bohemian Café (0.2 km).
- Available outside the main entrance.
- Elevators, ramps
- Available in the station.
- Bus: 135, 175, 207 Metro: C Train: All major s
- 06:00-23:00
- Free Wi-Fi
- Cafeteria Florenc (in the station)
- Bistro Florenc (0.2 km)
- Restaurace U Rozvařilů (0.5 km).
- Available outside the main entrance.
- Elevators, ramps
- Available in the station.
- Bus: 133, 135, 175, 207 Metro: B, C
- Free Wi-Fi
- Café Na Knížecí (in the station)
- Bistro Praha (0.2 km)
- Restaurace U Knížete (0.5 km).
- Available outside the main entrance.
- Elevators, ramps
- Available in the station.
- Bus: 137, 176, 191 Metro: B
More options for your journey from Karlsruhe to Prague
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