The cheapest and fastest buses from Prague to Brussels
Cheapest price
€45
Average price
€72
Fastest journey
12 h
Average duration
15 h 32 m
Buses per day
14
Distance
717 km
The best way to find a cheap bus ticket from Prague to Brussels is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Prague to Brussels will cost around €72 if you buy it on the day, but the cheapest tickets can be found for only €45.
Of the 14 buses that leave Prague for Brussels on Fri, Nov 21, 2 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Fri, Nov 21 the direct buses cover the 717 km distance in an average of 15 h 32 m but if you time it right, some buses will get you there in just 12 h .
On Fri, Nov 21 the slowest buses will take 17 h 10 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.
(Prague -> London)
FlixBus · FlixBus
FlixBus · FlixBus
FlixBus · FlixBus · FlixBus
FlixBus · FlixBus
(Prague -> London)
FlixBus
FlixBus · FlixBus
FlixBus · FlixBus
FlixBus · FlixBusTravel Information
Compare train, bus, and flight for Prague to Brussels
Omio recommends booking the flight as it is the most popular option from Prague to Brussels among Omio's users. If you are prioritising price take the bus with prices starting from €27. For those with little time consider booking a flight which can get you there in 2h 27m. In case you are seeking to minimise your carbon footprint the train is your best bet as it emits only 0.2 - 0.6kg. The ticket price range depends on the travel mode: a bus costs an average of €27, and a flight costs an average of €34.
Distance: 717 km
Compare bus with
| Bus | Most popular Flight | Train |
|---|---|---|
€66 Average price Cheapest | €192 Average price | €161 Average price |
14h 9m Average total duration 13h 39m Onboard + 30m Additional time* | 5h 27m Average total duration Fastest 2h 27m Onboard + 3h 0m Additional time* | 13h 42m Average total duration 13h 12m Onboard + 30m Additional time* |
0.7 - 1.8kg CO2 emissions | 2.2 - 4.3kg CO2 emissions | 0.2 - 0.6kg CO2 emissions Lowest |
![]() Most popular bus company | ![]() Most popular airline | ![]() Most popular train company |
Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
Live departures
Prague to Brussels bus times
The table below shows live departures for Prague to Brussels buses for today, Thursday, November 20. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
FlixBus · FlixBus · FlixBus | 4:50 AM Prague, Central Train Station | 19h50 | 12:40 AM Brussels, Brussels South (Gare du Midi) | 2 transfers | |
FlixBus · FlixBus | 7:30 AM Praha, ÚAN Florenc | 17h10 | 12:40 AM Brussels, Brussels South (Gare du Midi) | 1 transfer | |
FlixBus · FlixBus · FlixBus | 8:55 AM Praha, Zličín | 17h40 | 2:35 AM Brussels, Brussels South (Gare du Midi) | 2 transfers | |
FlixBus · FlixBus | 9:30 AM Praha, ÚAN Florenc | 17h05 | 2:35 AM Brussels, Brussels South (Gare du Midi) | 1 transfer | |
FlixBus · FlixBus | 9:55 AM Praha, Na Knížecí | 16h40 | 2:35 AM Brussels, Brussels South (Gare du Midi) | 1 transfer | |
FlixBus · FlixBus | 11:50 AM Praha, M. Horákové (Hradčanská) | 18h30 | 6:20 AM Brussels, Brussels South (Gare du Midi) | 1 transfer | |
FlixBus | 3:15 PM Praha, ÚAN Florenc | 15h05 | 6:20 AM Brussels, Brussels South (Gare du Midi) | 0 transfersDirect | |
FlixBus · FlixBus · FlixBus | 3:45 PM Prague, Central Train Station | 19h40 | 11:25 AM Brussels, Avenue des Magnolias (King Baudouin) | 2 transfers | |
FlixBus · FlixBus | 4:45 PM Praha, Na Knížecí | 19h00 | 11:45 AM Brussels, Brussels South (Gare du Midi) | 1 transfer | |
FlixBus · FlixBus | 5:00 PM Praha, ÚAN Florenc | 18h25 | 11:25 AM Brussels, Avenue des Magnolias (King Baudouin) | 1 transfer | |
30513 · 1466 | 6:00 PM Praha, ÚAN Florenc | 18h30 | 12:30 PM Brussels, Brussels South (Gare du Midi) | 1 transfer | |
FlixBus · FlixBus | 7:15 PM Praha, ÚAN Florenc | 19h20 | 2:35 PM Brussels, Brussels South (Gare du Midi) | 1 transfer | |
FlixBus · FlixBus | 7:40 PM Praha, Na Knížecí | 18h55 | 2:35 PM Brussels, Brussels South (Gare du Midi) | 1 transfer | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Prague to Brussels by train, bus, or flight
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Nov 20
Nov 21
Nov 22
Nov 23
Nov 24
Nov 25
Nov 26
Nov 27
Nov 28
Nov 29
Nov 30
Dec 01
Dec 02
Dec 03
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Dec 05
Dec 06
Dec 07
Dec 08
Dec 09
Dec 10
Journey information
Overview: Bus from Prague to Brussels
Buses from Prague to Brussels run on average 25 times per day, taking around 13h 39m. Cheap bus tickets for this journey start at €27 if you book in advance.
There are 3 buses per day. The earliest bus runs at 00:10, the last at 23:50. The fastest bus covers the 717 km distance in 12h 0m.
Distance 717 km |
Average bus duration 13h 39m |
Cheapest ticket price €27 |
Buses per day 25 |
Direct buses 3 |
Fastest bus 12h 0m |
First bus 00:10 |
Last bus 23:50 |
Bus providers: FlixBus, BlaBlaCar Bus from Prague to BrusselsYou can travel by bus between Prague to Brussels with FlixBus, BlaBlaCar Bus for as low as €27. When you search for schedules and tickets, Omio will show you the best journey
FlixBus
BlaBlaCar Bus
FAQs: Bus from Prague to Brussels
Find answers to the most common questions about traveling from Prague to Brussels by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Brussels, this guide helps you travel smarter and with confidence.

Passengers board the coach most frequently from Prague, Central Train Station, which is located around 1.8 miles (2.9 km) away from the city centre, and they get off the coach at Bruxelles, Gare du Nord, located 1.1 miles (1.7 km) away from the city centre.
To find the cheapest bus tickets for your trip from Prague to Brussels, follow these tips:
Start your search now and compare ticket prices to find the best deal!
popular bus stations
Popular bus stations from Prague to Brussels
- Free Wi-Fi
- Café Na Knížecí (in the station)
- Bistro Praha (0.2 km)
- Restaurace U Knížete (0.5 km).
- Available outside the main entrance.
- Elevators, ramps
- Available in the station.
- Bus: 137, 176, 191 Metro: B
- 00:00-23:59
- Free Wi-Fi
- Czech Bistro (in the station)
- Fast Food Express (in the station)
- Bohemian Café (0.2 km).
- Available outside the main entrance.
- Elevators, ramps
- Available in the station.
- Bus: 135, 175, 207 Metro: C Train: All major s
- 06:00-23:00
- Free Wi-Fi
- Cafeteria Florenc (in the station)
- Bistro Florenc (0.2 km)
- Restaurace U Rozvařilů (0.5 km).
- Available outside the main entrance.
- Elevators, ramps
- Available in the station.
- Bus: 133, 135, 175, 207 Metro: B, C
- 00:00-23:59
- Free Wi-Fi
- Cafeteria Černý Most (in the station)
- Czech Bistro (in the station)
- Fast Food Express (in the station).
- Available outside the main entrance.
- Elevators, ramps
- Available in the station.
- Bus: 177, 195, 201 Metro: B
- Bus: 131, 174, 180 Metro: A Train: S4, S5
- 06:00-23:59
- Free Wi-Fi
- Cafeteria Noord (in the station)
- Quick Brussels Noord (in the station)
- Le Pain Quotidien (0.5 km).
- Available outside the main entrance.
- Elevators, ramps
- Available in the station.
- Bus: 14, 57, 58 Metro: 2, 6 Train: IC, S1, S2
- 06:00-23:00
- Free Wi-Fi
- Cafeteria Midi (in the station)
- Belgian Bites (in the station)
- Fritland Express (0.5 km).
- Available outside the main entrance.
- Elevators, ramps
- Available in the station.
- Bus: 27, 49, 50, 78 Metro: 2, 6 Train: IC, S, Thalys, Eurostar
- The place has an entrance that is wheelchair-accessible
Most popular bus connections from Prague
More options for your journey from Prague to Brussels
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